SYSTEMATIC REVIEW article
Front. Pediatr.
Sec. Genetics of Common and Rare Diseases
Volume 13 - 2025 | doi: 10.3389/fped.2025.1566590
Prevalence of IVIG Resistance in Kawasaki Disease: A Systematic Review and Meta-Analysis
Provisionally accepted
Shuting Zou*
Bingyu Hu- Jiashan First People's Hospital, Jiaxing, China
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Background: Kawasaki Disease (KD) is an acute vasculitis primarily affecting children, with intravenous immunoglobulin (IVIG) being the standard treatment and leading to increased risk of coronary artery abnormalities.Objective: This systematic review and meta-analysis aim to evaluate the prevalence of IVIG resistance in KD and identify potential predictors and outcomes associated with this resistance.A comprehensive search of PubMed, Medline, Embase, and other relevant databases was conducted to identify studies reporting IVIG resistance in KD patients. Data on prevalence rates, patient demographics, and associated factors were extracted and analyzed.The analysis included 26 studies with a total of 46,461 patients. The overall prevalence of IVIG resistance was found to be 14 % (95% CI:12%-16%), and The prevalence among males and females was 9% (95% CI; 7% to 10%) and 4% (95% CI; 3.7% to 4.3%), respectively.IVIG resistance remains a significant challenge in the management of KD.Identifying patients at higher risk for IVIG resistance and developing alternative treatment strategies are crucial for improving outcomes in this population.
Keywords: kawasaki disease, IVIG resistance, Prevalence, and related keywords, randomized controlled trials, and clinical outcomes
Received: 25 Jan 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Zou and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuting Zou, Jiashan First People's Hospital, Jiaxing, China
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