ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Neurology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1567221
This article is part of the Research TopicNew Insights into Pediatric Neurology: Neurological Disorders and Epileptic EncephalopathiesView all 5 articles
Cytokine dysregulation in children with Severe Neurological Impairment correlates with significant clinical outcomes
Provisionally accepted
John Allen1,2,3,4
Johana Isaza-Correa1,3
Lynne Kelly1,3
Ashanty Melo1,3Aoife Mahony2
Conor Power5Denise McDonald2
Eleanor J Molloy2,3,4,6,7*- 1Trinity Centre for Health Sciences, Trinity Research in Childhood Centre, School of Psychology, Trinity College Dublin, Dublin, Ireland
- 2Children's Health Ireland, Tallaght University Hospital, Dublin, Ireland
- 3Department of Paediatrics, School of Medicine, Trinity College Dublin, Dublin, County Dublin, Ireland
- 4Our Lady's Children's Hospital (CHI), Crumlin, County Dublin, Ireland
- 5University College Dublin, Dublin, County Dublin, Ireland
- 6Trinity Research in Childhood Centre, School of Psychology, Trinity College Dublin, Dublin, Ireland
- 7Coombe Women & Infants University Hospital, Dublin, Ireland
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Children with neurological disorders have altered inflammatory responses. We aimed to describe pro-inflammatory, anti-inflammatory and hypoxia-induced cytokines in serum, at baseline, and in response to stimulation of whole blood with lipopolysaccharide, in children with Severe Neurological Impairment (SNI) compared to controls.Whole blood samples from children with SNI and healthy controls were incubated at in the presence or absence of lipopolysaccharide (LPS). Serum was isolated and 12 cytokines were analysed by ELISA.Select clinical data was collected from healthcare records and correlated with cytokine results.Twenty-nine children with SNI (n=14) and age-matched controls (n=15) were recruited. Cytokine
Keywords: cytokine, severe neurological impairment, Inflammation, lipopolysaccharide, ELISA
Received: 26 Jan 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Allen, Isaza-Correa, Kelly, Melo, Mahony, Power, McDonald and Molloy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Eleanor J Molloy, Trinity Research in Childhood Centre, School of Psychology, Trinity College Dublin, Dublin, Ireland
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