BRIEF RESEARCH REPORT article
Front. Pediatr.
Sec. Pediatric Critical Care
Volume 13 - 2025 | doi: 10.3389/fped.2025.1574398
This article is part of the Research TopicNovel targets in pediatrics: advances in diagnostic and therapeutic approachesView all 13 articles
Use of renal contrast-enhanced ultrasound to explore renal cortical microcirculation abnormalities in pediatric acute kidney injury
Provisionally accepted
- Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Objective To explore the correlation between the quantitative analysis curve of renal contrast-enhanced ultrasound and the anatomical location of renal cortical microcirculation associated with acute kidney injury.This study included a 1-year-and-11-month-old female child with acute kidney injury caused by drug overdosed and a 14-year-old female child with acute kidney injury caused by drug intentional, who were treated at Shanghai Children's Medical Center affiliated with Shanghai Jiao Tong University School of Medicine.Both patients underwent renal contrast-enhanced ultrasound and quantitative analysis.In addition, their clinical medical history data were recorded.The first child developed acute kidney injury owing to cyclosporine A overdosed. Contrast-enhanced ultrasound revealed poor cortical blood flow perfusion in both kidneys, with abnormally prolonged cortical perfusion times and possible obstruction of vascular inflow pathways. The second child experienced acute kidney injury owing to ibuprofen intentional. Contrast-enhanced ultrasound showed good cortical blood wash-in/perfusion but significantly delayed wash-out/excretion.The structure and function of the glomerulus significantly influence the perfusion rate and intensity of the rising branch of the curve. Furthermore, the descending branch of the curve is affected by the interplay of the capillaries surrounding the renal tubules. Exploration of these anatomical structures aids in understanding the renal microcirculation pathways and provides further insight into renal perfusion dynamics.
Keywords: Acute Kidney Injury, contrast-enhanced ultrasound, renal perfusion, Microcirculation, Renal haemodynamics, Child
Received: 10 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Yi, Zhang, Shi, Zhang and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jian Zhang, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Juan Du, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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