CASE REPORT article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1580368
Lead poisoning in a 10-year-old boy with cyclic vomiting as the first symptom: a case report
Provisionally accepted
- West China Second University Hospital, Sichuan University, Chengdu, China
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Lead is a naturally occurring metal with highly toxic effects on humans, particularly children, who are particularly vulnerable to its long-lasting adverse impacts.Patient concerns: This report presents the case of a 10-year-old boy with a 10-month history of recurrent vomiting. No organic lesions were identified. However, the symptoms were inconsistent with cyclic vomiting syndrome (CVS), given the presence of growth retardation, vitamin D deficiency, bilateral cervical lymphadenopathy, academic difficulties, and impaired concentration.Diagnosis: Detailed history-taking revealed proximity to a lead mining facility. Blood lead level (BLL) was significantly elevated (382 μg/L), confirming chronic lead poisoning.Interventions: Chelation therapy with dimercaptosuccinic acid (DMSA) was administered for 19 days at a 350 mg/m2 dose per administration.Outcomes: Following treatment, BLL decreased to 168 µg/L, accompanied by significant improvement in vomiting and abdominal pain.Pediatric lead poisoning should be considered in the differential diagnosis of children presenting with cyclic vomiting and neurological symptoms, due to its diagnostic complexity.
Keywords: Lead Poisoning, Cyclic vomiting, Cyclic vomiting syndrome, Neurological involvement, pediatric
Received: 20 Feb 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Ding, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiling Wang, West China Second University Hospital, Sichuan University, Chengdu, China
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