ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Critical Care
Volume 13 - 2025 | doi: 10.3389/fped.2025.1582551
Long-term neurological outcomes of severe traumatic brain injury in the Intensive Care Unit
Provisionally accepted
- Medical University of Silesia, Katowice, Poland
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Severe traumatic brain injury (TBI) remains the leading cause of acquired disability in previously healthy children, with outcomes varying widely despite advanced care. Post-traumatic brain damage may prevent proper functioning despite the implementation of advanced intensive care techniques or early neurosurgical interventions. This retrospective cohort study examined the relationship between specific intensive care unit (ICU) interventions and functional outcomes in 69 pediatric patients with severe TBI treated at the Upper Silesian Children's Health Center in Katowice from 2019-2024. Data collected included demographics, injury severity, treatment modalities, and intervention procedures. Long-term neurological outcomes were assessed using the Glasgow Outcome Scale (GOS) via parental interviews. The survival rate was 85.5% (59/69), with median ICU stay of 8 days (interquartile range [IQR] = 5-11). Of note, the survival rate was significantly longer in boys (8 days, IQR = 6-12.25) than girls (6 days, IQR = 3-9) (p = 0.021). Almost all patients (97.1%) required sedation upon admission, with median mechanical ventilation duration of 6 days (IQR = 4-8). This was also longer among boys (7 days, IQR = 4-9.25) than girls (5 days, IQR = 2-7) (p = 0.032). Poorer neurological outcomes (lower GOS scores) were significantly associated with longer ventilation duration (p < 0.001), vasopressor administration (p = 0.002), transfusion of red blood cells (RBC, p < 0.001) and transfusion of frozen plasma (FFP, p = 0.009). Intubation site did not significantly affect GOS scores (p = 0.659). Our findings suggest that pediatric TBI patients requiring prolonged ventilatory support, hemodynamic stabilization, and blood product administration face increased risk of unfavorable outcomes, highlighting the need for early transfer to specialized pediatric trauma centers to optimize recovery potential. Early referral and access to specialized centers can enhance recovery and improve long-term neurological outcomes.
Keywords: Severe traumatic brain injury, Pediatric intensive care, cerebral edema, Mannitol, Long-term neurological outcome
Received: 24 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Kołodziejczyk, Damps, Żmudka and Mandera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bartłomiej Kołodziejczyk, Medical University of Silesia, Katowice, Poland
Maria Damps, Medical University of Silesia, Katowice, Poland
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