ORIGINAL RESEARCH article
Front. Pediatr.
Sec. General Pediatrics and Pediatric Emergency Care
Volume 13 - 2025 | doi: 10.3389/fped.2025.1583429
This article is part of the Research TopicNovel targets in pediatrics: advances in diagnostic and therapeutic approachesView all 17 articles
Campylobacter Infection Presenting as Pseudo-appendicitis in Children: Identifying Predictors for Early Diagnosis
Provisionally accepted
Michael Schnapper1,2
Yaara Kahan2,3
Amir Klivitsky2,4Alex Guri5,6Rachel Shatzman Steuerman2,7,8Maya Heled Akiva2,3
Diana Tasher2,3*- 1Pediatrics, Wolfson Medical Center, Holon, Israel
- 2School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
- 3Pediatric Infectious disease Unit, Wolfson Medical Center, Holon, Tel Aviv District, Israel
- 4Pediatric Infectious Disease Unit, Dana-Dwek Children's Hospital, Tel Aviv, Israel
- 5Pediatrics, Kaplan Medical Center, Rehovot, Central District, Israel
- 6Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Jerusalem, Israel
- 7Pediatric Infectious Disease Unit, Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel
- 8Pediatrics, Meir Medical Center, Kfar Saba, Central District, Israel
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To characterize Campylobacter enteritis presenting as pseudo-appendicitis and identify distinguishing predicting factors.Methods: This retrospective multicentre study included all children <18 years with confirmed Campylobacter infection, hospitalized from 2014 to 2023 for presumed appendicitis (pseudo-appendicitis group). Each case was matched with 2 controls with confirmed appendicitis. Multivariable logistic regression analysis was conducted to determine the potential predictors for pseudo-appendicitis.Results: Fifty-five cases of pseudo-appendicitis were compared with 110 cases of appendicitis. The rate of peritoneal signs was similar between the two groups (78.2% vs.75.5% ,P=0.07). Computed-tomography (CT) scans were performed nearly twice as often in the pseudo-appendicitis group (38% vs.20%, P=0.01). Broad-spectrum
Keywords: 17.2, 95%CI:4.7-62.9, P<0.01), WBC <12, 000/μL (OR:9.6, 95%CI:2.9-31, sonographic signs of enlarged mesenteric lymphadenopathy and/or ileocolitis (OR:5.8, 95%CI:1.8-18.6
Received: 25 Feb 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Schnapper, Kahan, Klivitsky, Guri, Shatzman Steuerman, Heled Akiva and Tasher. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Diana Tasher, Pediatric Infectious disease Unit, Wolfson Medical Center, Holon, Tel Aviv District, Israel
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