ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1586985
Comparison of the Oxygenation Index and the Oxygen Saturation Index as Clinical Indicators for Neonatal ECMO
Provisionally accepted
- University of Kentucky, Lexington, Kentucky, United States
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Introduction: Neonatal hypoxic respiratory failure is commonly assessed with the oxygenation index (OI) to determine severity and guide ECMO initiation. Calculation of the OI requires arterial blood sampling which can be difficult to obtain. A non-invasive alternative, the oxygen saturation index (OSI), has shown promise, but its utility in ECMO determination is not welldescribed. We aimed to evaluate the correlation between the OI and OSI in neonates requiring ECMO.Children's Hospital (2012-2022) and analyzed OI and OSI values in the 12 hours preceding ECMO initiation.Results: A moderate correlation was observed between the OI and OSI. An OSI >17.41 predicted ECMO initiation, and OI can be estimated with the equation: OI = 1.978(OSI) -6.743.These findings suggest OSI may be a useful adjunct to OI for assessing neonatal respiratory failure and could be beneficial when arterial sampling is impractical.
Keywords: Neonatal ECMO, Oxygenation index, Oxygen saturation index, Persistent Pulmonary Hypertension, Neonatal hypoxemic respiratory failure
Received: 03 Mar 2025; Accepted: 05 Jun 2025.
Copyright: © 2025 Slaughter, Sites, Ballard, BAUER, Schadler and Severyn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nicholas Severyn, University of Kentucky, Lexington, 40506, Kentucky, United States
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