ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 13 - 2025 | doi: 10.3389/fped.2025.1589770
This article is part of the Research TopicMethods In Pediatric Infectious Diseases 2024View all 9 articles
Prognosis of different types of acute infection in the first episode of childhood acute leukemia
Provisionally accepted
- The Second Affiliated Hospital of Harbin Medical University, Harbin, China
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Objective: To determine the prognosis of different types of acute infection in pediatric leukemia patients.Methods: A retrospective study was carried out in cases with acute infections in pediatric leukemia patients admitted to the Second Affiliated Hospital of Harbin Medical University between September 1, 2004 and August 31, 2022. Clinical characteristics, diagnosis, and prognosis were extracted from the qualified patients and analyzed.Results: There were 36 cases of acute myeloid leukemia (AML) and 72 cases of acute lymphoblastic leukemia (ALL) who met the criteria of enrollment. There were significant differences in the incidence of pneumonia (47.2% vs. 27.8%, p=0.045) and sepsis (19.4% vs. 2.8%, p=0.006) between the AML and ALL groups. There were 10 cases with poor prognosis and 26 cases with favourable prognosis in the AML group. No significant difference exists between the poor prognosis and the favourable prognosis groups except in age (14.2±1.2 vs. 9.6±4.3, p=0.003). There were 14 cases with poor prognosis and 58 cases with favourable prognosis in the ALL group. No significant difference exists between the poor prognosis and the favourable prognosis groups except in age (13.4±2.7 vs. 9.2±4.7, p=0.002).Conclusions: There were significantly more incidence of pneumonia and sepsis in children with AML. Younger AML and ALL children with acute infections have more favourable prognosis than older ones.
Keywords: prognosis, acute infection, acute pediatric leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Children
Received: 07 Mar 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Li, Li, Chen, Jia, Luan and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shasha Li, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
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