ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Surgery
Volume 13 - 2025 | doi: 10.3389/fped.2025.1590586
This article is part of the Research TopicGastrointestinal Infections in Pediatric PopulationsView all 3 articles
Effect of Human serum albumin on clinical outcomes in pediatrics with gastrointestinal surgery
Provisionally accepted
- 1Department of Clinical Nutrition, Children's Hospital of Soochow University, Suzhou, China
- 2Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, China
- 3Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China
- 4Department of General Surgery, Children's Hospital of Soochow University, Suzhou, China
- 5Surgical Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, China
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To evaluate the effectiveness of administering 20% human serum albumin (HSA) on short-term clinical outcomes in pediatric patients undergoing enter anastomosis, with a specific focus on postoperative hospital stay (PHS), postoperative fasting duration (PFD), and the incidence of postoperative complications (PC).This was a single-center, retrospective cohort study. Patients aged between 1 month and 18 years who underwent simple intestinal anastomosis were included. Comprehensive data, including patient demographics, prescribed medications, laboratory test results, and surgical records, were meticulously extracted from the electronic patient dossiers. The primary endpoint was PHS. The second endpoint included PFD and PC. Since the cohort study was retrospective, we used propensity score matching (PSM) to balance different variables. The efficacy of 20% HSA on clinical outcomes was assessed by univariate and multivariate logistic regression.Among a cohort of 242 patients, 67 (27.69%) were administrated of 20% HSA for over 2 days at early stay after surgery. A dose-related pattern of HSA efficacy on clinical outcomes had been observed in the PSM cohort. After adjustment, HSA overuse was an independent risk factor for prolonged PHS and higher complication incidence, with odds ratios of 6.56 (95% confidence interval (CI) 2.12-20.32) and 5.14 (95% CI 1.21-21.83), respectively.Overuse of 20% HSA in the early postoperative stage does not contribute to improved clinical outcomes in pediatric patients undergoing gastrointestinal surgery.
Keywords: Human serum albumin, Hospital stay, Fasting duration, complication, Pediatrics
Received: 09 Mar 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 Li, ZHOU, Chen, Liu, Liu, Xu, Wang and GUI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: HUAN GUI, Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, 215003, Jiangsu Province, China
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