Your new experience awaits. Try the new design now and help us make it even better

CASE REPORT article

Front. Pediatr.

Sec. Pediatric Pulmonology

Volume 13 - 2025 | doi: 10.3389/fped.2025.1590800

This article is part of the Research TopicProgress in clinical and mechanistic studies of severe respiratory viral infections in childrenView all 4 articles

Virus infection induced exacerbations of lung injury and fibrosis in the children with diffuse alveolar hemorrhage: report of three cases

Provisionally accepted
Qing  WeiQing WeiJing  LiuJing LiuXUN  CHENXUN CHENChunyan  LiChunyan LiGuangmin  NongGuangmin NongYan  LiYan Li*
  • First Affiliated Hospital, Guangxi Medical University, Nanning, China

The final, formatted version of the article will be published soon.

Virus infection is a common cause of lung injury and can result in lung fibrosis in severe case. Furthermore, virus infection is an important trigger of exacerbation in the disease with lung fibrosis. Whereas, nearly all the cases or cases series reports focused on the adult population rather than pediatric population. Here, we reported three cases of virus infection induced exacerbations of lung injury and fibrosis in the children with diffuse alveolar hemorrhage. Also, this is one of the first article to report virus infection induced lung injury and fibrosis in children.

Keywords: Virus infection, Lung injury and fibrosis, Diffuse alveolar hemorrhage, Ground glass opacity, interlobular septal thickening

Received: 10 Mar 2025; Accepted: 29 Jul 2025.

Copyright: © 2025 Wei, Liu, CHEN, Li, Nong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yan Li, First Affiliated Hospital, Guangxi Medical University, Nanning, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.