ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fped.2025.1592550
This article is part of the Research TopicPrenatal Environmental and Genetic Interactions: An Exploration from Fetal Development to Child HealthView all articles
The impact of gestational diabetes mellitus on maternal-fetal pregnancy outcomes and fetal growth: A multicenter longitudinal cohort study
Provisionally accepted
Mi Su1Yangyang Wang2Qinqin Yuan1Dongmei Tang1Yu Lu1Xixi Wu1Wen Xiong1
Yalan Li3Tianjiao Liu1*
Siyuan Zeng4
Sumei Wei1- 1Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
- 2Chengdu Xinjin District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 3Chengdu Fourth People's Hospital, Chengdu, China
- 4West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
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Objective: To investigate the impact of gestational diabetes mellitus (GDM) on maternal and neonatal pregnancy outcomes and fetal growth patterns.Methods: A cohort of 418 pregnant women was analyzed, comprising 203 with normal glucose tolerance and 215 diagnosed with GDM. Key maternal factors, including age, pre-pregnancy body mass index (BMI), gestational weight gain, and gestational hypertension, were assessed for their association with infant growth and food allergy outcomes. At six months of corrected gestational age, weight-for-age z-scores (WAZ) and food allergy incidence were compared between the two groups.Binary logistic regression and linear regression analyses were performed to identify significant predictors of these outcomes.Infants born to mothers with GDM exhibited significantly higher WAZ scores (p = 0.026) and an increased neonatal susceptibility to food allergies (p = 0.043) compared to those born to mothers with normal glucose tolerance. Maternal factors such as advanced age, higher pre-pregnancy BMI, gestational hypertension, and twin pregnancy were identified as key risk factors for GDM. Additionally, preterm birth, birth weight, and parental history of allergies were independently associated with the development of food allergies in infants.: GDM exerts a notable influence on infant growth trajectories and elevates the risk of food allergies. Effective glycemic management during pregnancy, early monitoring of infant development, and targeted interventions addressing risk factors such as preterm birth and parental allergy history are critical for mitigating long-term health risks in children exposed to GDM in utero. Further research is warranted to explore the underlying mechanisms and potential preventive strategies for this at-risk population.
Keywords: cohort study, food allergies, gestational diabetes mellitus, Infant growth, Maternal-neonatal
Received: 12 Mar 2025; Accepted: 08 May 2025.
Copyright: © 2025 Su, Wang, Yuan, Tang, Lu, Wu, Xiong, Li, Liu, Zeng and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tianjiao Liu, Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
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