CASE REPORT article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1594539
A 14-year-old Boy with Recurrent Pancreatitis and Autism: Response to Steroid and Rituximab Therapy
Provisionally accepted
- Taichung Veterans General Hospital, Taichung, Taiwan
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ABSTRACT We report the case of a 14-year-old boy with a history of recurrent pancreatitis, autism, and learning disabilities who presented with non-bilious vomiting, epigastric pain, and a progressively enlarging abdominal mass. He was diagnosed with IgG4-related autoimmune pancreatitis (AIP). Initial corticosteroid therapy achieved only temporary remission, with disease relapse occurring after four months. Rituximab was subsequently introduced, resulting in sustained disease control by depleting B lymphocytes and reducing disease flares, consistent with previous reports. The patient has remained clinically stable for one year. This case highlights the clinical presentation, diagnostic challenges, and therapeutic considerations of this rare condition.
Keywords: IgG4-related disease, Autoimmune pancreatitis, pediatric pancreatitis, Pancreatic Pseudocyst, Autism Spectrum Disorder
Received: 16 Mar 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Lu, Lin and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yen-Chu Huang, Taichung Veterans General Hospital, Taichung, Taiwan
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