ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Cardiology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1598695
Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2-5 weeks of age
Provisionally accepted
- 1Department of Women's and Children's Health, Karolinska Institute (KI), Stockholm, Sweden
- 2Department of Pediatric Cardiology, Karolinska University Hospital, Stockholm, Stockholm, Sweden
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Newborns with CDH had reduced cardiac function measured with LV LS (mean -14.7% (standard deviation 4.6) vs -18.8% (2.7), p<0.001), RVFWS (-13.9% (4.2) vs 22.4% (4.8) p<0.001), LASr (22.8% (9.3) vs 33.9% (8.2), p<0.001), and RASr (21.8% (6.9) vs 37.6% (9.2), p<0.001), compared with controls. Cardiac strain had improved for all subjects at the age of 2-5 weeks. However, the cases with CDH still had lower strain than the controls.Cardiac function measured as strain was reduced in newborns with CDH compared with in a control group. Although their cardiac function improved over time, it remained lower compared to the control group at 2-5 weeks of age.
Keywords: CDH, Congenital Diaphragmatic Hernia, cardiac function, neonates, Strain
Received: 23 Mar 2025; Accepted: 17 Jun 2025.
Copyright: © 2025 Tydén, Magnusson, Burgos, Jonsson and Nordenstam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Katarina Overmo Tydén, Department of Women's and Children's Health, Karolinska Institute (KI), Stockholm, Sweden
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