CASE REPORT article
Front. Pediatr.
Sec. Pediatric Oncology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1600823
A pediatric case report with clear cell variant of mucoepidermoid carcinoma in the palate and harboring with MAML2 gene rearrangement
Provisionally accepted
Hengkun Wang*
Xiaoya Wang- Weihai Municipal Hospital, Weihai, China
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The clear-cell variant of mucoepidermoid carcinoma (MEC) is a rare subtype of MEC, and pediatric cases are extremely rare. A 13-year-old girl presented with a lesion on the right palate which had been noted for three months. The patient reported pain, rupture and bleeding of the tumor for nearly a month. Computer tomographic scans revealed a quasi-circular soft tissue mass of the right hard palate. Microscopically, the tumor cells showed predominant clear cells and scattered mucous cells. The tumor cells were positive for cytokeratin (CK), CK7, CK5/6, epithelial membrane antigen (EMA), P63 and P40. Rearrangement of mastermind-like transcriptional coactivator 2 (MAML2) (11q21) gene was identified in the tumor cells by fluorescence in situ hybridization. The histological features supported a diagnosis of clear-cell variant of MEC, medium grade, with tumor stage pT1N0M0. The patient underwent a complete excision of palatal mass, and after that superficial bone removal was performed. After surgery, the patient recovered well with recurrence-free at 1-year follow-up. Based on repeated pathological evidence, we report a rare pediatric case report with clear cell variant of MEC in the palate. Only surgical resection resulted in a favorable outcome.
Keywords: Mucoepidermoid carcinoma, Clear cell variant, MAML2 gene rearrangements, pediatric case report, Palate
Received: 27 Mar 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hengkun Wang, Weihai Municipal Hospital, Weihai, China
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