SYSTEMATIC REVIEW article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1611345
This article is part of the Research TopicEvaluating Efficacy and Outcomes in Neonatal HIE Treatment: A Global PerspectiveView all 5 articles
Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: A four-decade bibliometric exploration of emerging therapeutic dimensions (1985-2024)
Provisionally accepted
- 1THE AFFILIATED CHILDREN’S HOSPITAL OF KUNMING MEDICAL UNIVERSITY, Kunming, China
- 2The First People’s Hospital of Yunnan Province, Kunming, China
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Aim: Neonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remains inconsistent. Research topics and trends in this area remain unclear as well. This study aimed to identify key research areas, collaboration networks, and emerging trends using bibliometric analysis tools. Methods: A comprehensive analysis was conducted on 1,165 records from the Web of Science Core Collection (WoSCC) database. Various bibliometric techniques were employed, including coauthor analysis, co-occurrence analysis, co-citation analysis, reference clustering, and topic modeling, to visualize the knowledge structure and research dynamics in the HIE field.The findings revealed extensive collaboration networks among authors, institutions, and countries, highlighting global efforts to address this critical neonatal condition. Recent trends identified key research areas, including TH, mild systemic hypothermia, oxidative stress, biomarkers and signaling pathways, which are essential for advancing the understanding and treatment of HIE.This study provides valuable insights into the current TH for neonates with HIE. Future research should focus on optimizing treatment approaches and evaluating long-term efficacy to enhance clinical applications. Highlights • Bibliometric analysis of 1,165 studies reveals global collaboration networks and emerging HIE research trends, including therapeutic hypothermia (TH) optimization.• Key focuses: pathogenesis, therapeutic hypothermia and emerging treatments.• Future priorities: refining TH protocols and evaluating long-term neurodevelopmental outcomes to improve clinical translation.
Keywords: Therapeutic hypothermia, hypoxic-ischemic encephalopathy, biomarkers, Signaling Pathways, Emerging treatments, bibliometric analysis
Received: 14 Apr 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Shu, Liu, Yuan, Ma and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingjing Yang, The First People’s Hospital of Yunnan Province, Kunming, China
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