ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Urology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1612706
Pathological markers of Piezo1 at distal anastomosed ureter in predicting pyeloplasty outcomes in children
Provisionally accepted
- 1Jianhu People’s Hospital, Yancheng Shi, China
- 2Department of Urology, Nanjing Children's Hospital, Nanjing, China
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Objective: To evaluate the prognostic value of Piezo1 expression in the distal anastomosed ureter for predicting pyeloplasty outcomes. Methods: Distal anastomosed ureter specimens from 28 patients diagnosed with primary ureteropelvic junction obstruction (UPJO) undergoing laparoscopic pyeloplasty were analyzed. Immunohistochemistry assessed Piezo1 expression, and Masson's trichrome staining determined the collagen-to-muscle ratio (CM ratio). Postoperative outcomes at 12 months were categorized as excellent improvement, good improvement, mild improvement, no improvement, or deterioration based on hydronephrosis severity scores (HSS). Associations between pathological markers (Piezo1 and CM ratio) and surgical outcomes were examined. Results: The cohort included 28 patients (22 male, 6 female), with a median age of 64.3 months (IQR: 15.4-102.6). Compared to the unsatisfactory outcome group (no improvement/deterioration), the satisfactory group (excellent/good/mild improvement) exhibited significantly lower Piezo1 expression and CM ratio in the distal anastomosed ureter. Piezo1 expression strongly correlated with CM ratio (r = 0.687, p < 0.0001). Piezo1 expression level threshold of <2.765% predicted satisfactory outcomes. Conclusion: Distal anastomosed ureter Piezo1 expression is a promising prognostic biomarker for pyeloplasty outcomes.
Keywords: Piezo1, pathological markers, Distal ureter, Predictive Value, pyeloplasty outcomes
Received: 16 Apr 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Jincai, Xun, Liqu and Yunfei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guo Yunfei, guozhaooso@163.com
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