REVIEW article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1613832
Addressing the Silent Threat: Managing Invasive Candida Infections in Hospitalized Newborns
Provisionally accepted
- The Affiliated Hospital of Southwest Medical University, Luzhou, China
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Invasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality.Candida species (Candida spp.) are the major fungal pathogens, which cause the so-called invasive Candida infections (ICIs). Of these, Candida albicans is the most commonly isolated species, followed by Candida parapsilosis. Other identified Candida spp. include Candida glabrata, Candida tropicalis, Candida krusei, etc. However, an increasing shift in the epidemiology of ICIs worldwide has been described, non-albicans Candida (NAC) spp. ICIs pose a growing threat to neonates. Herein, we examine the epidemiology of Candida spp. infections, patterns of antifungal resistance, risk factors, prevention strategies, clinical outcomes, and treatment recommendations for ICIs in hospitalized newborn infants. This review aims to provide a thorough understanding of the current evidence on ICIs to better inform targeted prevention strategies and improved treatments to reduce neonatal morbidity and mortality.
Keywords: antifungal resistance, invasive Candida infections (ICIs), Newborn infants, pathogens, Prevention strategies, Risk factors, treatments
Received: 17 Apr 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Zhang, Xie, Yuan, He, Dong and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenbin Dong, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Xiaoping Lei, The Affiliated Hospital of Southwest Medical University, Luzhou, China
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