ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 13 - 2025 | doi: 10.3389/fped.2025.1620206
The value of combined examination of serum serum heparin binding protein, tumor necrosis factor alpha, interleukin-6, platelet count, and c-reactive protein in evaluating the condition and prognosis of children with adenovirus pneumonia
Provisionally accepted
- 1Qingdao Chengyang District People's Hospital, Qingdao, China
- 2Anqiu Women and Children's Hospital, Weifang, China
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Background: Adenovirus pneumonia presents a significant challenge in pediatric care, with severe children leading to significant morbidity. The study evaluated the combined prognostic value of serum Heparin Binding Protein (HBP), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), platelet count (PLT), and C-Reactive Protein (CRP) levels in assessing the condition and prognosis of children with adenovirus pneumonia. Methods: This retrospective study analyzed children with adenoviral pneumonia at our hospital from March 2019 to December 2024. Serum levels of HBP, TNF-α, IL-6, PLT, and CRP were measured. Participants were divided into non-severe and severe groups, and further into good and poor prognosis groups, based on clinical criteria and complications. Statistical analyses compared biomarker levels across these groups and evaluated their prognostic accuracy using receiver operating characteristic (ROC) curve analysis. Results: Elevated serum levels of HBP, TNF-α, IL-6, and CRP were significantly associated with severe adenovirus pneumonia (P < 0.001) in 300 children. Lower PLT was noted in severe children (P < 0.001). The composite model exhibited a high predictive accuracy with an AUC of 0.945 for disease severity and 0.940 for prognosis. Conclusion: The combination of serum HBP, TNF-α, IL-6, PLT, and CRP effectively predicted disease severity and prognosis in pediatric adenovirus pneumonia.
Keywords: Adenovirus pneumonia, Pediatrics, biomarkers, Prognostic model, Inflammatory Response, Heparin binding protein
Received: 16 May 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Wang, Liu, Yu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuzhen Cao, Anqiu Women and Children's Hospital, Weifang, China
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