ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1622610
This article is part of the Research TopicPlacental Dysfunction in Pregnancy: Endocrine and Metabolic Mechanisms in Preeclampsia, FGR, Diabetes, and HypertensionView all 5 articles
Effects of pre-eclampsia/eclampsia on platelet parameters in small for gestational age preterm infants
Provisionally accepted
- 1shantou university, shantou, China
- 2West China Children's Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China
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Objectives: To investigate whether pre-eclampsia/eclampsia (PE/E) alters platelet parameters, including platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW), in small for gestational age (SGA) infants. Methods: We enrolled 245 SGA preterm infants between 2020 and 2023. They were grouped according to their mother's PE/E status. We assessed the PLT, MPV, PDW, and prevelence of thrombocytopenia during the first 30 days after birth. Groups were compared using either χ2 test or Fisher's exact test. Results: SGA neonates born to mothers with PE/E had a lower PLT on Day 7 than those born to mothers without PE/E (P = 0.0211). PDW and MPV values gradually increased for the first several days, and eventually stabilized around the first week. There was no statistical difference in MPV, PDW, or thrombocytopenia prevalence between SGA neonates between born to mothers with PE/E and those born to mothers without PE/E. Conclusions: Evidence to support an association between PE/E and platelets parameter in neonates is limited. SGA may be the real reason for alterations in platelet parameters in neonates.
Keywords: Pre-Eclampsia, Eclampsia, Platelet, Thrombocytopenia, small for gestational age
Received: 04 May 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Huang, Zhao, Huang, Ai and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tingting Zhu, West China Children's Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China
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