REVIEW article
Front. Pediatr.
Sec. Pediatric Oncology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1625359
Recent advances in the study of reproductive function in pediatric patients with brain tumors
Provisionally accepted
- 1West China Hospital, Sichuan University, chengdu, China
- 2Chongqing Medical University, chongqing, China
- 3West China Hospital, Sichuan University, Chengdu, China
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In recent years, pediatric brain tumors have emerged as one of the most common malignant tumors among children. The site of tumor growth and the selected treatment modalities can potentially have a profound and significant impact on the reproductive function of pediatric patients, which is intimately associated with the physical and psychological health of children during their developmental process.Current research studies have demonstrated that pediatric patients diagnosed with germ cell tumors, craniopharyngiomas, and medulloblastomas commonly present with reproductive dysfunction. Regrettably, in clinical practice, neurosurgeons frequently fail to allocate sufficient attention to this particular aspect. It is of critical and urgent necessity to explore and elucidate the alterations in reproductive function among pediatric patients with brain tumors, and subsequently institute essential protective measures. This article is dedicated to comprehensively reviewing the latest research advancements regarding the relationship between pediatric brain tumors and reproductive function, thereby providing a valuable reference for safeguarding the reproductive function of pediatric patients afflicted with brain tumors.
Keywords: pediatric, brain tumors, Neuroendocrinology, reproductive function, HPG axis
Received: 08 May 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Zhang, Liu, Dai, Ju and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanming Ren, West China Hospital, Sichuan University, Chengdu, China
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