CASE REPORT article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1625557
This article is part of the Research TopicInnate and Adaptive Immunity of Normal and Adverse PregnancyView all 6 articles
Neonatal Anemia Due to Spontaneous Fetomaternal Hemorrhage in a Term Neonate: A Case Report of an Incidental Finding and Brief Review
Provisionally accepted
- 1Department of Blood Transfusion, ShengJing Hospital of China Medical University, Shenyang, China
- 2Immunohematology Reference Laboratory， Shanghai Blood Center, Shanghai, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Fetomaternal hemorrhage, a rare perinatal condition involving transplacental transfer of fetal erythrocytes into maternal circulation, poses significant risks of fetal anemia, hydrops, and maternal alloimmunization which remains underdiagnosed due to nonspecific presentations and limited diagnostic accessibility. We present a term neonate delivered via cesarean section at 38 weeks' gestation with severe anemia and hyperbilirubinemia. Blood group analysis revealed maternal-neonatal Rh incompatibility, while flow cytometry quantified 2.0% fetal erythrocytes in maternal blood. This case underscores the diagnostic utility of integrating blood group serology and flow cytometry in FMH confirmation, particularly when standard tests yield equivocal results. Multidisciplinary evaluation of the fetus is the key to early diagnosis and intervention to improve the clinical outcome of perinatal infants.
Keywords: Fetomaternal hemorrhage, Neonatal anemia, Flow Cytometry, Blood group serology, Rh incompatibility, Perinatal Mortality
Received: 09 May 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Hao, Zhang, Gao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiushi Wang, Department of Blood Transfusion, ShengJing Hospital of China Medical University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.