CASE REPORT article
Front. Pediatr.
Sec. Pediatric Orthopedics
Volume 13 - 2025 | doi: 10.3389/fped.2025.1626146
Disseminated BCG infection in a child with multifocal osteomyelitis due to STAT1 LOF variant and primary immunodeficiency disease was significantly improved after anti -tuberculosis treatment: a case report
Provisionally accepted
- Children‘s Hospital of Chongqing Medical University, Chongqing, China
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Background: This was a rare case where the diagnosis was not obvious during treatment, but the treatment was effective after diagnosis. An infant with recurrent fever was considered for systemic multiple osteomyelitis after two surgical biopsies. After a third operation to take a lymph node biopsy, the patient was finally diagnosed as having disseminated Bacille Calmette-Guerin(BCG) disease caused by BCG vaccination. After diagnosis, the child was effectively treated with anti-tuberculosis therapy. Case description: A 2-month-old female patient was hospitalized twice for fever and surface mass. The patient underwent a puncture biopsy of the right tibia and a puncture biopsy of the lesion of the right leg respectively. The patient was diagnosed with systemic multiple osteomyelitis. The patient still had recurrent fever after antibiotic treatment. At outpatient follow-up, the patient was found to have primary immunodeficiency disease with STAT1 LOF mutation. When the child was one year and one month old, she was hospitalized again with a fever. The patient underwent a third operation, a biopsy of the left axillary lymph node. The pathological results suggested granulomatous inflammation, which was considered tuberculosis. The child was diagnosed with disseminated BCG vaccine disease.After 16 months of oral treatment with isoniazid, rifampicin, ethambutol,and levofloxacin, the child's condition was significantly improved. Conclusions: The performance of multiple surgical biopsies is crucial in cases of infants presenting with recurrent fever and widespread bone destruction, as well as in children diagnosed with primary immunodeficiency disease, particularly when the available etiological tests offer limited diagnostic evidence.
Keywords: case report, BCG vaccine disease, Systemic multiple osteomyelitis, Anti-tuberculosis therapy, Primary immunodeficiency disease
Received: 10 May 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Ouyang, Yang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongliang Wang, Children‘s Hospital of Chongqing Medical University, Chongqing, China
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