ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Hematology and Hematological Malignancies
Volume 13 - 2025 | doi: 10.3389/fped.2025.1627990
This article is part of the Research TopicTreatment of Viral Infections Following Hematopoietic Stem Cell TransplantationView all articles
Analysis of Risk Factors for Epstein-Barr Virus (EBV) Reactivation and Progression to Post-transplant Lymphoproliferative Disorder (PTLD) in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Provisionally accepted
- Children‘s Hospital of Chongqing Medical University, Chongqing, China
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Background: Post-transplant infections are common complications, and the reasons are pretransplant conditioning, time required for post-transplant immune reconstitution, and use of immunosuppressive agents. We aimed to analyze the risk factors for Epstein-Barr virus (EBV) reactivation and its progression to post-transplant lymphoproliferative disorder (PTLD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children and to determine the EBV PCR diagnostic threshold for PTLD.
Keywords: allogeneic hematopoietic stem cell transplantation, pediatric, Epstein-Barr virus (EBV), Reactivation, Post-transplant lymphoproliferative disorder (PTLD)
Received: 13 May 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Jia, Yang, Ya, Meng, Zhang, Lei, Guan, Yu and Dou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Dou, Children‘s Hospital of Chongqing Medical University, Chongqing, China
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