ORIGINAL RESEARCH article

Front. Pediatr.

Sec. Children and Health

Volume 13 - 2025 | doi: 10.3389/fped.2025.1629765

The Influence of Varied Parenteral Nutrition Protocols on the Surgical Incidence and Prognosis of Retinopathy of Prematurity in Preterm Neonates

Provisionally accepted
Yafei  SunYafei Sun1Teng  WangTeng Wang1Ruixia  LinRuixia Lin1Xuejun  XuXuejun Xu2*
  • 1Qingdao Chengyang District People's Hospital, Qingdao, China
  • 2The Fifth People's Hospital of Qingdao, Qingdao, China

The final, formatted version of the article will be published soon.

Objective: This retrospective cohort study aimed to assess the impact of different parenteral nutrition (PN) protocols on the incidence and prognosis of retinopathy of prematurity (ROP) in preterm infants.Methods: Medical records of 87 preterm infants admitted to the neonatal intensive care unit between October 2019 and October 2022 were retrospectively analyzed. The infants were non-randomly allocated into two groups based on the PN protocols they received: the fish oil group(41 cases) received PN with high n-3 fatty acid-containing lipid emulsions, while the non-fish oil group(46 cases) received PN with medium and long-chain lipid emulsions. Fatty acid profiles were assessed on the first day of hospitalization and after 14 days of PN. The incidence of ROP at 4 and 6 weeks after birth was compared, along with the time taken to regain birth weight, achieve full enteral feeding, duration of mechanical ventilation, and ROP surgical rate during hospitalization.Results: On the first day of hospitalization, there were no significant differences in DHA, EPA, and AA levels between the two groups. However, after 14 days of PN, the fish oil group showed significantly higher DHA levels and lower AA levels compared to the non-fish oil group. The fish oil group required less time to achieve full enteral feeding compared to the non-fish oil group. There were no significant differences in other blood parameters between the two groups. The levels of liver enzymes (ALT,TBA,AST,γ-GT) were significantly lower in the fish oil group. There were no significant differences in the overall incidence of ROP and mild ROP between the two groups at 4 and 6 weeks after admission. However, the fish oil group had a significantly higher incidence of severe ROP and a significantly lower surgical rate compared to the non-fish oil group.Conclusion: Early administration of lipid emulsions enriched with n-3 fatty acids in preterm infants has a preventive effect on severe ROP. This intervention is associated with higher serum DHA levels and lower AA levels, shorter time to achieve full enteral feeding, and reduced surgical rate for ROP. Further research is needed to optimize PN strategies in preterm infants with ROP.

Keywords: preterm infants, n-3 fatty acid-enriched lipid emulsions, medium/long-chain lipid emulsions, Retinopathy of Prematurity, Parenteral Nutrition

Received: 16 May 2025; Accepted: 09 Jul 2025.

Copyright: © 2025 Sun, Wang, Lin and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Xuejun Xu, The Fifth People's Hospital of Qingdao, Qingdao, China

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