ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1632735
This article is part of the Research TopicAdvances and Challenges in Neonatal Surgery: Congenital and Acquired ConditionsView all 30 articles
Early Assessment and Analysis of High-risk Factors of Neurodevelopmental Impairment in Neonates with Congenital Diaphragmatic Hernia(CDH)
Provisionally accepted
Boliang Bai1,2*
Wendong Liu1Ronghui Yu1Xueping Zhu1Wenqiang Sun1Lang Jiang1Xiaodong Wang1*Guanghao Su1- 1Soochow University Medical College, Suzhou, China
- 2Soochow University, Suzhou, China
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Background:This study aimed to retrospectively analyze clinical data of neonates with congenital diaphragmatic hernia (CDH) to investigate risk factors for neurodevelopmental impairment and their prognosis, and to evaluate the predictive value of combined assessment using amplitude-integrated electroencephalography (aEEG), regional cerebral oxygen saturation (rSO₂), and Neonatal Behavioral Neurological Assessment (NBNA) for early intervention.Methods:A total of 83 neonates with CDH (36 in the neurodevelopmental impairment group and 47 in the control group) were included, all diagnosed by prenatal ultrasound and postnatal imaging, with exclusion of other congenital malformations, hemodynamic instability, and genetic disorders.Clinical data (e.g., lung-to-head ratio [LHR],postoperative pulmonary hypertension, surgical approach), neuromonitoring indices (aEEG, rSO₂), and neurodevelopmental assessments (NBNA, Gesell Developmental Schedules) were collected. Independent risk factors for neurodevelopmental impairment and the area under the ROC curve (AUC) of aEEG, rSO₂, NBNA, and their combined assessment were analyzed.
Keywords: Congenital diaphragmatic hernia (CDH), neurodevelopmental impairment, Combined assessment, rSO2, LHR
Received: 21 May 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Bai, Liu, Yu, Zhu, Sun, Jiang, Wang and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Boliang Bai, Soochow University Medical College, Suzhou, China
Xiaodong Wang, Soochow University Medical College, Suzhou, China
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