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GENERAL COMMENTARY article

Front. Pediatr., 17 July 2025

Sec. Neonatology

Volume 13 - 2025 | https://doi.org/10.3389/fped.2025.1634333

Commentary: Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes


Huaijie WangHuaijie WangZhengtuan Guo

Zhengtuan Guo*
  • Department of Pediatric Surgery & Vascular Anomalies, Xi’an International Medical Center Hospital, Xi’an, China

A Commentary on

Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes

By Mao R, Ruan W, Zhu J, Li L, Jiang H and Li Y (2025). Front Pediatr. 13:1511892. doi: 10.3389/fped.2025.1511892

Introduction

In the article titled “Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes”, Mao et al. reported a neonate with hepatic congenital hemangioma (CH) treated with multidisciplinary managements, including oral propranolol and transarterial embolization (TAE) (1). We have a few comments on the diagnosis and management of hepatic CH, and some causes of encephalomalacia.

Comments and discussion

1. Hepatic CH is not infantile hemangioma, oral propranolol is incorrect. For medical management of vascular anomalies, beta blockers are only used to treat infantile hemangioma in current evidenced literature. Based on medical history and classic imaging findings provided by authors, a typical hepatic CH can be confirmed. The authors appeared to be unfamiliar with certain classic literature in the field (26).

2. Causes of severe iatrogenic encephalomalacia

Arteriovenous shunting and pulmonary hypertension are common in congenital hemangiomas. Following transarterial particulate embolization, embolic materials may migrate into the pulmonary arteries. In a pediatric patient with concurrent pulmonary hypertension, atrial septal defect, and patent ductus arteriosus, a right-to-left shunt (Eisenmenger phenomenon) could develop. This may allow embolic materials to bypass the pulmonary circulation and enter the left heart, ultimately leading to cerebral infarction. Therefore, the encephalomalacia is of iatrogenic origin and unrelated to the congenital hemangiomas. These contraindications of embolization can be found in some classic literature studies (7, 8).

Consequently, this is not a unique baby but a common case of hepatic CH, occurring severe iatrogenic sequelae. Therefore, we suggest that this article should be majorly revised or withdrawn.

Author contributions

HW: Conceptualization, Writing – original draft. ZG: Investigation, Supervision, Validation, Writing – review & editing.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declare that no Generative AI was used in the creation of this manuscript.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

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Keywords: hepatic congenital hemangioma, arteriovenous fistula, pulmonary hypertension, atrial septal defect, patent ductus arteriosus, Eisenmenger phenomenon, cerebral infarction, transarterial embolization

Citation: Wang H and Guo Z (2025) Commentary: Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes. Front. Pediatr. 13:1634333. doi: 10.3389/fped.2025.1634333

Received: 24 May 2025; Accepted: 2 July 2025;
Published: 17 July 2025.

Edited by:

Yi Ji, Sichuan University, China

Reviewed by:

Kaiying Yang, Guangzhou Women and Children’s Medical Center, China

Copyright: © 2025 Wang and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Zhengtuan Guo, Mzk3MTY2ODQ0QHFxLmNvbQ==

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.