ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1640331
Development of a nomogram for predicting postoperative Hirschsprung-Associated Enterocolitis (HAEC)
Provisionally accepted
- Fujian Provincial Maternity and Children's Hospital, Fuzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objectives: To analyze the risk factors for postoperative Hirschsprung-associated enterocolitis（HAEC）and establish a nomogram to predict the incidence of HAEC. Methods: All patients with Hirschsprung disease who underwent definitive surgery at Fujian Provincial Children's Hospital from January 2015 to December 2023 were included in the study. Univariate and multivariate logistic regression were used to analyze the influencing factors of chylous ascites and a nomogram was established. The predictive performance of the nomogram was evaluated using receiver operating characteristic(ROC) curves, calibration plots, and decision curve analysis(DCA) curves. Results: Of the included 204 patients, 53 patients(25.9%) experienced postoperative HAEC. Preoperative HAEC, the type of HSCR (long-segment or total colonic aganglionosis), no-preoperative bowel preparation, and anastomotic leaks or strictures were considered important risk factors. The area under the ROC curve of the model is 0.79, the nomogram has great discriminative ability, calibration and significant clinical utility. Conclusion: We found a nomogram for predicting the postoperative HAEC. It can be used as a reference for risk assessment and early detection of postoperative HAEC.
Keywords: nomogram, Hirschsprung-associated enterocolitis, Risk factors, Children, Predicting
Received: 03 Jun 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Zheng, Liu, Chen, Chen, Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ming-kun Liu, Fujian Provincial Maternity and Children's Hospital, Fuzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.