REVIEW article
Front. Pediatr.
Sec. Pediatric Cardiology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1645130
Cardiovascular Consequences of Bronchopulmonary Dysplasia in Preterm Infants: Current Insights and Future Directions
Provisionally accepted
Bohan Zhang1
Qian Liu2*- 1Zhejiang University School of Medicine Children's Hospital, Hangzhou, China
- 2Tianyou Hospital affiliated to Tongji University, Shanghai, China
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Bronchopulmonary dysplasia (BPD) is a chronic pulmonary condition predominantly associated with preterm birth. Exposure to high concentrations of oxygen, mechanical ventilation, and perinatal infections disrupts normal alveolarization and pulmonary vascular development through complex pathophysiological mechanisms, contributing to the onset of BPD and pulmonary hypertension (PH). Persistent PH and elevated pulmonary vascular resistance compromise right ventricular function. Moreover, ventricular interdependence may result in impaired left ventricular performance, adversely influencing cardiovascular development in affected infants. These cardiovascular impairments may persist into adulthood, potentially contributing to long-term morbidity. This review examines both the short-term and long-term cardiovascular consequences of BPD in preterm infants, with a focus on pulmonary vascular disease, biventricular dysfunction, systemic vascular abnormalities, and the interrelationship between BPD and cardiovascular pathology.
Keywords: Bronchopulmonary Dysplasia, Left ventricle, pulmonary hypertension, right ventricle, patient ductus arteriosus (PDA)
Received: 11 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qian Liu, Tianyou Hospital affiliated to Tongji University, Shanghai, China
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