ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Neurology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1646261
Novel serum biomarker for powerfully predicting pediatric simple febrile seizures
Provisionally accepted
- 1Jinhua Maternal and Child Health Care Hospital, Jinhua, China
- 2Zhejiang University, Hangzhou, China
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Objective: Current model or biomarkers are far from satisfactory to predict pediatric simple febrile seizures (SFS). This study aimed to explore novel serum biomarkers in children with SFS and analyze their clinical significance. Methods: A total of 57 SFS children admitted to the pediatric ward of Jinhua Maternal and Child Health Hospital from June 2022 to October 2024 were enrolled as the observation group, 61 sepsis patients and 45 healthy children from the pediatric health clinic during the same period were included as the control groups. Serum levels of 25-hydroxyvitamin D and diverse cytokines were measured using enzyme-linked immunosorbent assay (ELISA). Univariate logistic regression was used to identify the predictive ability of risk factors for SFS Results: The SFS group exhibited significantly lower levels of IL-17 (SFS: 5 vs.Health: 12 and Sepsis: 16) compared to the control groups. Conversely, the SFS group showed significantly higher levels of pro-inflammatory cytokines (IFN-α: 22 vs. 4 and 5; and IL-10: 12 vs. 10 and 9) than the control groups. ROC curve revealed that during SFS episodes, IFN-α can powerfully in discriminating SFS and health cohorts.Serum level of IFN-α hold significant predictive value for SFS occurrence.
Keywords: febrile seizures, IL-6, IFN-α, Vitamin D, ROC Curve
Received: 16 Jun 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Mei, Hu, Sheng, Wang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wangxiong Hu, Zhejiang University, Hangzhou, China
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