ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1651612
Epidemiology of inflammatory bowel disease-associated anemia in children and adolescents from 1990-2021: a global, regional analysis from the global burden of disease study
Provisionally accepted
- Nanjing Medical University, Nanjing, China
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Objective: Inflammatory bowel disease (IBD)-associated anemia cannot be ignored because it can affect the growth and development of children and adolescents. The study aimed to report the global, regional, and national disease burden of IBD-associated anemia in children and adolescents. Methods: The prevalence of IBD-associated anemia and years lived with disability (YLDs) are available according to the Global Burden of Diseases 2021. Joinpoint Regression Analysis, age-period cohort modeling analysis, and decomposition analysis were performed. Finally, the ARIMA model was established to predict the disease burden up to 2041. Results: Anemia associated with IBD was more prevalent among 15 to 19-year-olds, and the prevalence number was significantly higher in females (11487.26, 95% [UI] = 8826.54,14622.31) than in males (6677.01, 95% [UI] = 5179.56,8498.89). The age-standardized prevalence rate (ASPR) was highest in moderate anemia (17.5561, 95% [UI] = 14.9597,20.8729). Joinpoint regression analysis suggested the ASPR of IBD-associated anemia in both males and females increased from 2005 to 2010 and then decreased after 2010. In the decomposition analysis, aging and population growth were the main drivers of changes in the prevalence of IBD-associated anemia. ASPR exhibits a fluctuating trend in males from 1990 to 2041 and is projected to remain stable in females from 2027 to 2041. Conclusion: The ASPR of IBD-associated anemia in children and adolescents increased from 2005 to 2010 and then decreased after reaching a peak in 2010. In the future, IBD-associated anemia will still be an essential public health problem.
Keywords: inflammatory bowel disease, Anemia, Global burden of disease, Children, adolescents
Received: 26 Jun 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Xu, Mao, Xu and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiufang Cui, cuixiufang1988@126.com
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