ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1658405
25OH Vitamin D3 in biliary atresia: a simple and under-utilised diagnostic method
Provisionally accepted
- 1新疆医科大学第一附属医院, 乌鲁木齐市, China
- 2First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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Background:Biliary atresia is a form of pediatric cholangiopathy that affects the bile ducts of the liver. If left undiagnosed and untreated, it often leads to liver failure and death within 1-2 years of age. The treatment approach for this condition is recognized as the Kasai surgical procedure,which has been shown to achieve optimal outcomes when performed within 60 days of age. Furthermore, the timing of surgery has been identified as a crucial factor in determining patient prognosis. The current clinical practice involves the use of ultrasound as a primary diagnostic tool. Serum γ -glutamyltranspeptidase and other biochemical indicators are utilized in the diagnosis of biliary atresia, yet challenges persist regarding the occurrence of false-positive results. Consequently, there is an urgent clinical necessity to investigate non-invasive indicators for the early diagnosis of BA in children, with the objective of enhancing the accuracy of early diagnoses. In clinical practice, we frequently encounter cases of severe vitamin D deficiency in children diagnosed with BA. In recent years, the association between vitamin D and liver fibrosis in chronic liver disease has been substantiated. The objective of this study was to ascertain the clinical value and significance of 25(OH)D3 in the early diagnosis of BA.
Keywords: Biliary Atresia, Children, 25(OH)D3, under-utilised, diagnostic
Received: 03 Jul 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Song, Li, Chen, Maimaijiang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wanfu Li, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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