ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 13 - 2025 | doi: 10.3389/fped.2025.1660776
This article is part of the Research TopicNovel Diagnostics to Aid in Early Detection of Antimicrobial Resistance (AMR)View all 3 articles
Antibiotic optimization in hospitalized children with non-severe community-acquired pneumonia: lessons from an Antimicrobial Stewardship intervention (2022–2024)
Provisionally accepted
Federica Attaianese
Roberto Privato*
Carlotta Montagnani
Micol Stivala
Sandra Trapani
Luisa Galli
Giuseppe Indolfi- Azienda Ospedaliera Universitaria Meyer IRCCS - Firenze, Florence, Italy
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Background and objectives: Community-acquired pneumonia (CAP) is a leading cause of hospitalization and antibiotic use in children. Despite guidelines recommending narrow-spectrum regimens and shorter treatment durations, prescribing practices remain inconsistent. This study assessed the impact of a newly implemented diagnostic and therapeutic clinical pathway (CP) as part of an antimicrobial stewardship (AMS) intervention in a tertiary care pediatric hospital. Methods: A single-center, retrospective observational study was conducted on children aged 28 days to 18 years hospitalized with non-severe, uncomplicated CAP from January 2022 to December 2024. The CP was implemented on January 1st, 2024. Antibiotic prescribing patterns, clinical outcomes, and predictors of short-course therapy (≤5 days) were compared between pre- and post-CP periods. Multivariate logistic regression identified predictors of intravenous (IV) therapy ≤48 hours, total therapy ≤ 5 days, and ampicillin use as first-line agent. Results: The study included 263 CAP episodes in 250 children. Following the implementation of CP, the use of ampicillin as a first-line IV antibiotic significantly increased (19/99 [19%] vs. 1/164 [0.6%]; p < 0.001). A higher proportion of post-CP patients received IV antibiotics for ≤48 hours (25/99 [25%] vs. 20/164 [12%]; p = 0.006), reflecting an increased rate of early IV-to-oral switch. However, total antibiotic duration and hospital length of stay (LOS) remained unchanged. Viral detection in respiratory samples predicted antibiotic courses of ≤5 days. Conclusions: CP implementation improved adherence to evidence-based antibiotic prescribing, reduced broad-spectrum use, and increased early IV-to-oral transitions without compromising outcomes. However, unchanged therapy duration and LOS highlight the need for further AMS interventions, clinician education, and integration of viral and bacterial diagnostics to support optimal antibiotic use.
Keywords: Community-acquired pneumonia, Children, Antimicrobial stewardship, antibiotics, therapy duration
Received: 06 Jul 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Attaianese, Privato, Montagnani, Stivala, Trapani, Galli and Indolfi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Roberto Privato, roberto.privato@unifi.it
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