ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
This article is part of the Research TopicNew Discoveries and Challenges in Pediatric Infectious Diseases: Epidemiological, Clinical, and Pathogenic AdvancesView all 8 articles
Comparison of systemic inflammatory response index and systemic immune-inflammatory index in childhood community-acquired pneumonia between respiratory syncytial virus and Mycoplasma pneumoniae
Provisionally accepted
HuiHui Zhou1*
Kai-Li Qian2- 1Ningbo Yinzhou No 2 Hospital, Ningbo, China
- 2Ninghai First Hospital, Zhejiang, China
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Objective: The study aimed to compare systemic inflammatory response index (SIRI) and systemic immune-inflammatory index (SII) in pediatric community-acquired pneumonia (CAP) caused by respiratory syncytial virus (RSV) and Mycoplasma pneumoniae (Mp). Methods: The study included 120 children with single RSV infection (RSV group) and 120 with single Mp infection (Mp group). The SIRI and SII were calculated by neutrophil×monocyte/lymphocyte and platelet×neutrophil/lymphocyte, respectively. Results: Significant differences of RSV and Mp infections were found in three age-stratified subgroups including < 6 months, 3-5 years, and ≥ 5 years (p < 0.05). The proportions of children presenting nasal stuffiness and rhinorrhea, shortness of breath, grunting, and gastrointestinal symptoms were markedly higher in the RSV group than those in the Mp group (p < 0.05). The RSV group had lower values of SIRI and SII than the Mp group (p = 0.010; p = 0.021). The duration of symptoms before admission, LOS, proportions of children requiring oxygen supplementation and with severe pneumonia were significantly higher in the RSV group than the Mp group (p < 0.05). The incidence of bronchial pneumonia and emphysema was significantly higher in the RSV group than that in the Mp group (p = 0.005; p = 0.001). The incidence of patchy shadow was significantly higher in the Mp group than that in the RSV group (p = 0.027). Conclusion: SIRI and SII may provide additional value to distinguish CAP associated with RSV and Mp infections in children, both of which may serve as easily accessible blood indicators for clinical decision making in pediatric CAP management.
Keywords: Community-acquired pneumonia, respiratory syncytial virus, Mycoplasma pneumonia, systemic inflammatory response index, Systemic immune-inflammatory index
Received: 29 Aug 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Zhou and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: HuiHui Zhou, zhh19921009@163.com
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