CASE REPORT article
Front. Pediatr.
Sec. Pediatric Pulmonology
Mycoplasma pneumoniae-induced Rash and Mucositis (MIRM) in an 8-Year-Old Girl: Concise review of a challenging case
Provisionally accepted
Li Yunlong
Wang Hewen*- Rizhao People's Hospital, Rizhao, China
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We report an 8-year-old girl presenting with an 8-day history of cough, 5-day fever, and recent-onset conjunctival hyperemia and oral mucosal erosions. Laboratory testing confirmed Mycoplasma pneumoniae infection (IgM antibody and DNA positive). Chest X-ray demonstrated bilateral increased and blurred lung markings, consistent with acute bronchitis. Initial treatment with azithromycin and methylprednisolone sodium succinate (MPSS) improved respiratory symptoms but triggered a progressive rash involving the trunk, perineum, and anus. Adjuvant therapy with intravenous immunoglobulin (IVIG, 22.5 g) and continued immunomodulation with MPSS led to resolution of mucocutaneous manifestations by hospital day 10. This case highlights the potential for M. pneumoniae to induce systemic immune-mediated reactions and underscores the importance of multimodal therapy. Clinical trial number: not applicable.
Keywords: Mycoplasma pneumoniae, Rash, Mucositis, Child, diagosis
Received: 02 Sep 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Yunlong and Hewen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wang Hewen, 249816562@qq.com
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