CORRECTION article

Front. Pharmacol., 22 April 2021

Sec. Drug Metabolism and Transport

Volume 12 - 2021 | https://doi.org/10.3389/fphar.2021.630274

Corrigendum: Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

  • 1. Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United States

  • 2. MAK Scientific LLC, Burlington, MA, United States

  • 3. Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA, United States

  • 4. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, United States

  • 5. Protasis Corporation, Seabrook, NH, United States

Roger A. Kautz was not included as an author in the published article. The corrected Author Contributions Statement appears below.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Statements

Author contributions

CH: Designed and conducted experiments. XM and VJ: Metabolite scale up and NMR experiments. JW: Conducted animal PK experiments and data analysis. SK, AZ, and MM: Synthesized compound for studies and metabolite M1 for confirmation. RK and DS: assisted in setting up the microcoil probe and troubleshooting. CH, XM, and JG: Analyzed data and wrote the manuscript. JG and AM: Principal investigators oversaw the project, provided lab resources, and edited the manuscript.

Summary

Keywords

metabolite identification, LC-MS, micro-coil NMR, Adamantyl metabolism, di-hydroxyl adamantyl metabolite, CYP3A4 metabolism, CB2 agonist, cannabinoid metabolism

Citation

Honrao C, Ma X, Kulkarni S, Joshi V, Malamas M, Zvonok A, Wood J, Kautz RA, Strand D, Guo JJ and Makriyannis A (2021) Corrigendum: Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite. Front. Pharmacol. 12:630274. doi: 10.3389/fphar.2021.630274

Received

17 November 2020

Accepted

18 February 2021

Published

22 April 2021

Approved by

Frontiers in Pharmacology Editorial Office, Frontiers Media SA, Switzerland

Volume

12 - 2021

Updates

Copyright

*Correspondence: Jason J Guo, ; Alexandros Makriyannis,

Deceased.

This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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