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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1380098
This article is part of the Research Topic Reviews in Ethnopharmacology: 2023 View all 17 articles

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Provisionally accepted
Chang Gao Chang Gao 1Xiao-Di Song Xiao-Di Song 2*Fang-Hui Chen Fang-Hui Chen 1*Gui-Lin Wei Gui-Lin Wei 1*Chun-Yu Guo Chun-Yu Guo 1*
  • 1 First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 2 Gannan Medical University, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

    Keywords: Rheumatoid arthritis, Angiogenesis, mechanisms, Natural medicines, ingredients, VEGF

    Received: 01 Feb 2024; Accepted: 10 May 2024.

    Copyright: © 2024 Gao, Song, Chen, Wei and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao-Di Song, Gannan Medical University, Ganzhou, 121013, Jiangxi Province, China
    Fang-Hui Chen, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Gui-Lin Wei, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Chun-Yu Guo, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.