CORRECTION article

Front. Pharmacol., 08 November 2024

Sec. Inflammation Pharmacology

Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1404434

Corrigendum: Efficacy of hyaluronic acid in the treatment of nasal inflammatory diseases: a systematic review and meta-analysis

  • 1. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

  • 2. Chengdu Medical College, Chengdu, China

  • 3. Chengdu First People’s Hospital, Chengdu, Sichuan, China

In the published article, there was an error in Table 1 as published. The authors found that the occurrence of cephalgia was possibly related the use of nasal spray (Thieme et al., 2020), however, this was omitted in the meta-analysis. The final row of Table 1 (source Thieme et al., 2020) has been corrected to reflect this. The corrected Table 1 and its caption appear below.

TABLE 1

SourceCountryType of patientsDurationInterventionControl
Intervention
OutcomesAdverse event
Intervention method (Dose)Population
(Male)
Mean agemethod (Dose)Population
(Male)
Mean age
Cantone et al., 2016ItalyCRSwNP3 monthsMometasone furoate nasal spray (200μg, once daily)
SH plus saline solution (9mg, twice daily)
4056.9 ± 5.6αMometasone furoate nasal spray (200μg, once daily)
Saline solution (5mL, twice daily)
4056.8 ± 4.4αNasal Congestion, Rhinorrhea, Nasal Endoscopy Scoring, Quality of lifeNo adverse reactions
Casale et al., 2014ItalyCRS3 monthsSH plus saline solution (9mg, twice/day)21 (13)44 (30–63) βSaline solution (5mL, twice/day)18 (10)38 (34–58) βRhinitisNo adverse reactions
Cassandro et al., 2015ItalyCRSwNP3 monthsSH plus saline (9mg, twice daily)20 (12)38.75 ± 13.08αSaline (5mL, twice daily)20 (11)38.6 ± 13.06αRhinitis, Mucociliary clearance, Nasal Endoscopy Scoring, RhinomanometryHeadache, Throat irritation, Upper respiratory infection, Epistaxis, Nasal burning
Mometasone furoate nasal sprays (200μg, twice daily)
SH (9mg, twice daily)
20 (12)38.85 ± 13.31αMometasone furoate nasal sprays (200μg, twice daily)20 (10)38.4 ± 12.7α
Ciofalo et al., 2017ItalyARS30 daysLevofloxacin (500mg, 10days)
Prednisone (50mg, 8days; 25mg, 4days; 12.5mg, 4days)
SH plus saline solution (6mL, twice daily)
24 (12)44 (38–50) *Levofloxacin (500mg, 10days)
Prednisone (50mg, 8days; 25mg, 4days; 12.5mg, 4days)
Saline solution (6mL, twice daily)
24 (14)43 (35–55) *Nasal Congestion, Rhinorrhea, Eosinophils, Neutrophils, mucociliary clearance, HyposmiaNot reported
Ercan et al., 2022TurkeyAR in children28 daysNasal fluticasone furoate (1 puff/nostril, once daily)
SH (twice daily)
26 (18)8.38 ± 1.89αNasal fluticasone furoate (1 puff/nostril, once daily)
Saline solution (twice daily)
24 (12)8.5 ± 1.31αNasal Congestion, Rhinorrhea, Rhinitis, Itching, Sneezing, Eosinophils, Quality of life, RhinomanometryNasal irritation and burning sensation
Nasal fluticasone furoate (1 puff/nostril, once daily)
SH (twice daily)
26 (18)8.38 ± 1.89αNasal fluticasone furoate (1 puff/nostril, once daily)26 (18)8.69 ± 1.7α
Favilli et al., 2019ItalyPregnancy Rhinitisuntil deliverySH (9mg/vial; 2 vials daily for 14 days, followed by 15 days of interruption of therapy; subsequently 1 vial daily for 10 and 15 days of interruption of therapy; lastly 1 vial daily for 10 days)2831.6 ± 5.5αNot receive any treatment2728.1 ± 4.8αRhinorrheaNo adverse reactions
Gelardi et al., 2013ItalyAR and vasomotor rhinitis30 daysMometasone furoate nasal spray (50μg/spray, 2 sprays/nostril once daily)
Desloratadine (5mg, once daily)
SH (9mg, twice daily)
39 (23)21–63βMometasone furoate nasal spray (50μg/spray, 2 sprays/nostril once daily)
Desloratadine (5mg, once daily)
Sodium chloride (6mL, twice daily)
39 (21)22–61βNasal Congestion, Rhinorrhea, Eosinophils, NeutrophilsNot reported
Gelardi et al., 2016ItalyAR, NAR, and MR4 weeksintranasal mometasone furoate (1 puff/nostril, twice daily)
rupatadine fumarate (1 tablet daily)
isotonic saline solution (1 puff/nostril, twice daily)
SH (1 cm per nostril in the afternoon)
48Not reportedintranasal mometasone furoate (1 puff/nostril, twice daily)
rupatadine fumarate (1 tablet daily)
isotonic saline solution (1 puff/nostril, twice daily)
41Not reportedNasal Congestion, Rhinorrhea, Itching, Sneezing, HyposmiaNo adverse reactions
Ocak et al., 2021TurkeyAR30 daysTriamcinolone acetonide sprays (256 μg/day, 1 puff/nostril, once daily)
Desloratadine (5mg, once daily)
SH (9mg, twice daily)
32 (14)34 (18–68) βTriamcinolone acetonide sprays (256 μg daily, 1 puff/nostril, once daily)
Desloratadine (5mg, once daily)
Isotonic saline (9mg, twice daily)
33 (13)36 (18–61) βMucociliary clearanceNo adverse reactions
Savietto et al., 2020ItalyCRSsNP30 daysSH (5mg, twice daily)15Not reportedIsotonic saline solution (5mg, twice daily)15Not reportedNasal Congestion, Rhinorrhea, Eosinophils, Neutrophils, Nasal Endoscopy Scoring, Quality of life, HyposmiaNo adverse reactions
Thieme et al., 2020GermanyDry nose symptoms4 weeksSH (1–2 sprays/nostril)/Hyaluronic acid plus dexpanthenol (1–2 sprays/nostril)79 (41)/
80 (25)
54.15 ± 17.03α/50.60 ± 18.98αIsotonic saline (1–2 sprays/nostril)80 (31)
50.27 ± 19.7αNasal Congestion, Rhinorrhea, Rhinitis, Itching, Sneezing, HyposmiaCephalgia

Basic characteristics of included studies.

CRS, chronic rhinosinusitis; CRSwNP, chronic rhinosinusitis with nasal polyposis; CRSsNP, chronic rhinosinusitis without nasal polyposis; ARS, acute rhinosinusitis; NAR, nonallergic rhinitis; MR: mixed rhinitis; SH, sodium hyaluronate; α, Mean age ± SD; β, Mean age (range); *, median (IQR).

In the published article, there was an error. The authors found that the occurrence of cephalgia was possibly related the use of nasal spray (Thieme et al., 2020), however, this was omitted in the meta-analysis.

A correction has been made to 3 Results, 3.4 Outcomes, 3.4.4 Adverse events, Paragraph Number 1. The sentences previously stated:

“These studies (Cassandro et al., 2015; Ercan et al., 2022) reporting adverse events included nasal burning, headaches, throat irritation, upper respiratory tract infections, epistaxis, and nasal irritation. One trial (Cassandro et al., 2015) reported no difference in the incidence of adverse events between the HA and control groups, and the other trial (Ercan et al., 2022) showed only mild adverse events in the control group.”

The corrected sentence appears below:

“These studies (Cassandro et al., 2015; Ercan et al., 2022) reported adverse events including nasal burning, headache, throat irritation, upper respiratory tract infection, epistaxis, and nasal irritation. One patient reported thrice about the occurrence of cephalgia in hyaluronic acid plus dexpanthenol group, rated as possibly related to the application of the nasal spray (Thieme et al., 2020). One trial (Cassandro et al., 2015) reported no difference in the incidence of adverse events between the HA and control groups, and the other trial (Ercan et al., 2022) showed only mild adverse events in the control group.”

In the published article, there was an error in Table 1. In the final row, “α” was not in superscript. The corrected table and its caption appear above.

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Statements

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Summary

Keywords

hyaluronic acid, sodium hyaluronate, allergic rhinitis, sinusitis, nasal inflammatory diseases, meta-analysis

Citation

Liu H, Chen Y, Wang H, Luo X, Xie D, Ji Q and Tian L (2024) Corrigendum: Efficacy of hyaluronic acid in the treatment of nasal inflammatory diseases: a systematic review and meta-analysis. Front. Pharmacol. 15:1404434. doi: 10.3389/fphar.2024.1404434

Received

21 March 2024

Accepted

25 October 2024

Published

08 November 2024

Volume

15 - 2024

Edited and reviewed by

Pablo Andres Evelson, University of Buenos Aires, Argentina

Updates

Copyright

*Correspondence: Qing Ji, ; Li Tian,

†These authors have contributed equally to this work

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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