ORIGINAL RESEARCH article

Front. Pharmacol.

Sec. Ethnopharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1540092

This article is part of the Research TopicPharmacology of Natural Products against Neurodegenerative DisordersView all 13 articles

The Volatile Oil of Acorus tatarinowii Schott Significantly Attenuates Neuroinflammatory Damage in a Rat Model of Tourette Syndrome by Inhibiting the p38 MAPK/NLRP3/STAT3 Signaling Pathway

Provisionally accepted
Xing WeiXing Wei1Kexin SUNKexin SUN1Feng PengFeng Peng2*Shuang HuangShuang Huang1Bing JiangBing Jiang1Min CuiMin Cui1Yuanhuan ChenYuanhuan Chen1Fuchun XueFuchun Xue1Yuezhen HeYuezhen He3Jingxi YaoJingxi Yao1Jing ShangJing Shang1Hao MeiHao Mei1Yanqing DingYanqing Ding4Yongyan TianYongyan Tian2Guangyu GuoGuangyu Guo1Yang NanYang Nan1Zhenggang ShiZhenggang Shi1*
  • 1Gansu University of Chinese Medicine, Lanzhou, Gansu, China
  • 2Hexi University, Zhangye, China
  • 3First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
  • 4Zhangye People's Hospital, Zhangye, China

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ABBREVIATIONS AD Alzheimer's disease LSD Least Significant Difference ASC Apoptosis-associated speck-like protein containing a CARD M1 Classically Activated Microglia ASD Autism spectrum disorder M2 Alternatively Activated Microglia ANOVA Analysis of Variance MAPK Mitogen-Activated Protein Kinase BBB Blood-brain barrier NF-κB Nuclear factor kappa-B caspase-1 Cysteine-aspartic acid protease-1 NLR Nod-like receptor CD11b Cluster of differentiation 11b NLRP3 NOD-like receptor family, pyrin domain-containing 3 CD163 Cluster of differentiation 163 p38 MAPK p38 Mitogen-Activated Protein Kinase CD45+ Cluster of differentiation 45 p-p38 MAPK Phosphorylated p38 Mitogen-Activated Protein Kinase CNS Central nervous system p-STAT3 Phosphorylated Signal Transducer and Activator of Transcription 3 COX-2 cyclooxygenase-2VOA inhibits the p38 MAPK/NLRP3/STAT3 pathway, reducing neuroinflammation in TS rat.VOA repairs and protects neurons by regulating molecules like IL-6, IL-10, and COX-2.The experimental design employs multiple techniques assess VOA's efficacy.VOA shows potential as a treatment for TS and other neuroinflammatory diseases.

Keywords: Volatile Oil from Acorus tatarinowii, Tourette Syndrome, Neuroinflammation, p38 MAPK/NLRP3/STAT3, a rat model

Received: 05 Dec 2024; Accepted: 05 May 2025.

Copyright: © 2025 Wei, SUN, Peng, Huang, Jiang, Cui, Chen, Xue, He, Yao, Shang, Mei, Ding, Tian, Guo, Nan and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Feng Peng, Hexi University, Zhangye, China
Zhenggang Shi, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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