Pharmacology of Natural Products against Neurodegenerative Disorders

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ORIGINAL RESEARCH

Published on 29 Aug 2025

Systems pharmacology identifies ajugol-mediated NF-κB/caspase-3 inhibition and isoacteoside-driven p62/mTOR-mediated autophagy as key mechanisms of Rehmanniae Radix and its processed form in Alzheimer’s treatment

Xiang Han
Xianglong Meng
Yuhui Wu
Wei Xia
Simin Xue
Xiaoqin Liu
Chenzi Lyu
Ziang Li
Xiaoning Yan
1 more
Shuosheng Zhang

doi 10.3389/fphar.2025.1644847

360 views

ORIGINAL RESEARCH

Published on 28 Aug 2025

Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

Yun Hee Jeong
YeonGyun Jung
Wei Li
Hye Jin Yang
You-Chang Oh
Jong-Sup Bae

doi 10.3389/fphar.2025.1638068

363 views

SYSTEMATIC REVIEW

Published on 11 Jul 2025

Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis

Yuanhang Rong
Qinqing Li
Yuzhong Du
Wenting Wang
Wenna Su
Junlong Zhang
Wenbin He

doi 10.3389/fphar.2025.1603861

930 views

ORIGINAL RESEARCH

Published on 04 Jul 2025

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer’s disease

Xue Mi
Xinglin Ruan
Renyi Lin
Shuxin Huang
Ping Cai
Xiaochun Chen
Jiangfeng Liao
Xiaoman Dai

doi 10.3389/fphar.2025.1572771

1,544 views

REVIEW

Published on 27 Jun 2025

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases

Shijun Bi
Shibing Liu
Kunyuan Zhu
Dandan Gao
Ligang Chen
Chunyong Yu
Guobiao Liang

doi 10.3389/fphar.2025.1606146

1,398 views

MINI REVIEW

Published on 24 Jun 2025

Research on the effects of GLP-1 receptor agonists in treating cognitive dysfunction and gait disorders in elderly patients with diabetes

Yang Yang
Lifeng Chen
Yanjun Zhang
Wenqian Fu
Dandan Liu
Tianyu Jiang

doi 10.3389/fphar.2025.1607443

1,129 views

REVIEW

Published on 23 Jun 2025

Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies

Nahida Aktary
Yerim Jeong
Seungji Oh
Yeju Shin
Yoonsoo Sung
Muntajin Rahman
Livia Ramos Santiago
Jinwon Choi
Han Gyeul Song
3 more
Bonglee Kim

doi 10.3389/fphar.2025.1601712

2,757 views
1 citation

REVIEW

Published on 18 Jun 2025

Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis

WenQiang Li
E. Liu
YiHao Zhou
ZhiChao Liao
DongYan Wang

doi 10.3389/fphar.2025.1579172

1,558 views

ORIGINAL RESEARCH

Published on 11 Jun 2025

Neuroprotective potential of quercetin in Alzheimer’s disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-β aggregation

Mohd Adnan
Arif Jamal Siddiqui
Fevzi Bardakci
Malvi Surti
Riadh Badraoui
Mitesh Patel

doi 10.3389/fphar.2025.1593264

2,106 views
1 citation

ORIGINAL RESEARCH

Published on 27 May 2025

Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition

Yixin Zhang
Xin Zhang
Xiaocheng Shi
Weijing Liao
Junbin Lin

doi 10.3389/fphar.2025.1594283

1,340 views

DATA REPORT

Published on 23 May 2025

Psychoactive Plant Database: a phytochemical resource for neurological drug discovery

Harjot Kaur
Monika Gupta
Zabeer Ahmed
Amit Nargotra

doi 10.3389/fphar.2025.1569127

1,830 views

ORIGINAL RESEARCH

Published on 16 May 2025

Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes

Minzhen Deng
Yuefang Cai
Yu Wang
Dafeng Hu
Yan Li
Zhenqiu Ning
Chengyi Wang
Sookja Kim Chung
Yan Huang
3 more
Xiao Cheng

doi 10.3389/fphar.2025.1571552

1,086 views

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Frontiers in Pharmacology

Ethnopharmacology
Neuropharmacology

Participating Journals

Frontiers in Neuroscience
- Neuropharmacology
- 3.2 impact factor
- 6.6 citescore

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Articles

Systems pharmacology identifies ajugol-mediated NF-κB/caspase-3 inhibition and isoacteoside-driven p62/mTOR-mediated autophagy as key mechanisms of Rehmanniae Radix and its processed form in Alzheimer’s treatment

Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer’s disease

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases

Research on the effects of GLP-1 receptor agonists in treating cognitive dysfunction and gait disorders in elderly patients with diabetes

Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies

Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis

Neuroprotective potential of quercetin in Alzheimer’s disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-β aggregation

Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition

Psychoactive Plant Database: a phytochemical resource for neurological drug discovery

Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes

Frontiers in Pharmacology

Ethnopharmacology

Neuropharmacology

Participating Journals

Frontiers in Neuroscience

Neuropharmacology