MINI REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1607443
This article is part of the Research TopicPharmacology of Natural Products against Neurodegenerative DisordersView all 12 articles
Research on the Effects of GLP-1 Receptor Agonists in Treating Cognitive Dysfunction and Gait Disorders in Elderly Patients with Diabetes
Provisionally accepted
- 1Department of Neurology, Chinese PLA General Hospital, Beijing, China
- 2People's Liberation Army General Hospital, Beijing, Beijing Municipality, China
- 3Department of Neurosurgery, Chinese PLA General Hospital, Beijing, Beijing Municipality, China
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Elderly patients with Type 2 Diabetes Mellitus (T2DM) often experience cognitive dysfunction and gait disorders, which significantly affect their quality of life and daily function. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), known as "wonder drugs for weight loss," have shown potential not only for glycemic control but also for improving cognitive function and gait disturbances. GLP-1RAs may exert their effects through various mechanisms, including promoting neurogenesis and synaptic plasticity in the brain, as well as reducing neuroinflammation, thereby improving cognitive and gait impairments either directly or indirectly. This review aims to explore the role of GLP-1RAs in the treatment of diabetes-related cognitive dysfunction and gait disturbances, as well as their potential mechanisms, providing a theoretical basis for clinical treatment.
Keywords: GLP-1R agonist, Diabites mellitus, cognitive f unctions, Gait disorder, Parkinson ' s disease
Received: 07 Apr 2025; Accepted: 27 May 2025.
Copyright: © 2025 Yang, Chen, Zhang, Fu, Liu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tianyu Jiang, People's Liberation Army General Hospital, Beijing, 100853, Beijing Municipality, China
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