SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1582661
This article is part of the Research TopicHerbal Medicines’ Safety and Clinical Application: New Strategies for Overcoming Therapeutic ChallengesView all 12 articles
Efficacy and safety of 11 oral preparations of single-source traditional Chinese medicines in the treatment of unstable angina pectoris: A systematic review and network meta-analysis
Provisionally accepted
- 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 2Heart Center, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
- 3Department of Cardiovascular, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China
- 4Department of Cardiovascular, The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
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Background: Unstable angina pectoris (UAP) is a cardiovascular disease with high morbidity and can cause serious cardiovascular complications. Oral preparations of single-source traditional Chinese medicines (SSTCM-OPs) are increasingly used as adjuncts to conventional treatments (CT) for UAP, providing complementary therapeutic advantages with favorable safety profiles. However, the comparative efficacy and safety of these SSTCM-OPs remain unclear.This network meta-analysis (NMA) evaluates the efficacy and safety of 11 approved SSTCM-OPs to guide clinical practice in UAP treatment.: A comprehensive literature search was conducted across 8 databases: China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, China Biomedical Literature Database (CBM), Web of Science, PubMed, EMBASE, and the Cochrane Library. Only randomized controlled trials (RCTs) examining SSTCM-OPs combined with CT for UAP were included. The search covered publications up to
Keywords: Network meta-analysis, Traditional Chinese Medicine, Unstable angina pectoris, Oral preparation, Ethnopharmacology research
Received: 24 Feb 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Li, Li, Zhu, Xin, Sheng, Wang, Kan and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junming Kan, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Yongsheng Huang, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.