ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1583040
TCMAP: An evidence-based traditional Chinese medicine database for alleviating acute pancreatitis and its related complications Zhou X et al. A TCM database for alleviating AP
Provisionally accepted
- 1Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
- 2Chengdu Neusoft University, Chengdu, Sichuan, China
- 3Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
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Integrative medicine combining traditional Chinese medicine (TCM) with Western medicine has become a notable approach for treating acute pancreatitis (AP). However, the absence of a comprehensive and reliable database to store and organize TCM-related data for the prevention and treatment of AP presents a significant challenge for the development of herbal medicines. To develop a comprehensive, user-friendly platform for browsing, querying, and analyzing TCM-related data for treating AP. TCM-related data for treating AP were systematically extracted from the literature and established databases. The front-end interface was developed using HyperText Markup Language, Cascading Style Sheets, and JavaScript to enhance user experience. The back-end employed Hypertext Preprocessor and My Structured Query Language for improved performance and security. The Smarty template engine was utilized to separate the front-end and back-end, facilitating efficient updates to the TCMAP platform. The current version of the TCMAP includes: (i) documentation of 200 evidence-based TCM formulations, with comprehensive details on clinical applications, targets related to AP, and target pathway enrichment analysis, including 449 herbs; (ii) records of 58 natural compounds, involving extensive information on their potential targets and pharmacological properties; and (iii) integration with a web server enables users to conduct similarity and enrichment analyses of input prescriptions based on herbs, components, and genes. Furthermore, TCMAP also supports discovering anti-AP herb pairs with similar components and targets. Network analysis further provides users with the intrinsic properties of anti-AP formulations. The TCMAP provides a robust data platform for predicting new compounds and exploring the potential mechanisms of TCM in treating AP. The TCMAP is accessible at https://cellknowledge.com.cn/tcmap.
Keywords: Conceptualization, Data curation, investigation, methodology, visualization, Roles/Writing -original draft, Funding acquisition. Yu Yang: Data curation, Formal analysis
Received: 26 Mar 2025; Accepted: 27 May 2025.
Copyright: © 2025 Zhou, Yang, Liu, HAO, Ao, Liu, Zhang and Zhi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Zhou, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
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