In the published article, there was an error in Figure 1 as published. The patient numbers are listed as 377 --> 377 --> 304, but it should say 377 --> 305 --> 304. The corrected Figure 1 and its caption appear below.
FIGURE 1
Patient recruitment and selection flowchart.
In the published article, there was an error in Results,Algorithm for Acenocoumarol Dosing in the Chilean Population. In the formula two factors have decimals placed incorrectly. It’s a formatting error, but it is significant as it impacts the dose calculations.
The formula previously stated:
“Log WTD = 3.081 + (0.167 × men) - (age × 0.081) - (initial INR × 0.55) + (BMI × 0.013) - (CYP2C9*1/*2 × 0.107) - (CYP2C9*1/*3 × 0.323) - (CYP2C9*3/*3 × 0.746) - (VKORC1 G/A × 0.270) - (VKORC1 A/A × 0.701).”
The corrected formula appears below:
“Log WTD = 3.081 + (0.167 × men) - (age × 0.0081) - (initial INR × 0.055) + (BMI × 0.013) - (CYP2C9*1/*2 × 0.107) - (CYP2C9*1/*3 × 0.323) - (CYP2C9*3/*3 × 0.746) - (VKORC1 G/A × 0.270) - (VKORC1 A/A × 0.701).”
In the published article, there was an error in Results,Genotype Distribution in the Study Population, paragraph 1.
This sentence previously stated:
“The analysis of the HWE showed that only CYP2C9*3 (rs1057910) is in HWE (chi2 = 4.67). All other SNPs, VKORC1 (rs9923231) (chi2 = 0.09), VKORC1 (rs7294) (chi2 = 0.62), GGCx (rs11676382) (chi2 = 1.2), CYP4F2 (rs2108622) (chi2 = 1.02), ApoE (rs429358) (chi2 = 0.08), ABCB1 (rs1045642) (chi2 = 0.68), and CYP2C9*2 (rs1799853) (chi2 = 2.33), are not in HWE.”
The corrected sentence appears below:
“The analysis of the HWE showed that only CYP2C9*3 (rs1057910) is not in HWE (chi2 = 4.67). All other SNPs, VKORC1(rs9923231) (chi2 = 0.09), VKORC1 (rs7294) (chi2 = 0.62), GGCx (rs11676382) (chi2 = 1.2), CYP4F2 (rs2108622) (chi2 = 1.02), ApoE (rs429358) (chi2 = 0.08), ABCB1 (rs1045642) (chi2 = 0.68), and CYP2C9*2 (rs1799853) (chi2 = 2.33), are in HWE.”
The correspondence email for author Luis Abel Quiñones has been updated in the published article to lquinone@uchile.cl.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
acenocoumarol, coumarins, algorithm, pharmacogenetics, pharmacogenomics, anticoagulation
Citation
Roco A, Nieto E, Suárez M, Rojo M, Bertoglia MP, Verón G, Tamayo F, Arredondo A, Cruz D, Muñoz J, Bravo G, Salas P, Mejías F, Godoy G, Véliz P and Quiñones LA (2025) Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study. Front. Pharmacol. 16:1588440. doi: 10.3389/fphar.2025.1588440
Received
05 March 2025
Accepted
13 March 2025
Published
31 March 2025
Volume
16 - 2025
Edited and reviewed by
Nathalie K. Zgheib, American University of Beirut, Lebanon
Updates
Copyright
© 2025 Roco, Nieto, Suárez, Rojo, Bertoglia, Verón, Tamayo, Arredondo, Cruz, Muñoz, Bravo, Salas, Mejías, Godoy, Véliz and Quiñones.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Luis Abel Quiñones, lquinone@uchile.cl
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.