REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1594060
This article is part of the Research TopicThe Pharmacological Effects and Mechanisms of Drugs Against Human Diseases by Modulating Redox Homeostasis - Volume IIView all 9 articles
Potential of Functional Flavonoids in Targeting Vasospasm through Modulation of Oxidative Stress and SPC-induced Signaling Pathways
Provisionally accepted
- Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
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Vasospasm is a sustained abnormal contraction of vascular smooth muscle (VSM), which is commonly observed in the coronary and cerebral arteries. This abnormal VSM contraction leads to reduced blood flow to tissues or organs, ultimately causing severe diseases such as myocardial infarction and cerebral infarction. Studies have demonstrated that oxidative stress and sphingosylphosphorylcholine (SPC)-induced Rho-kinase signaling pathways are related to this abnormal contraction. Flavonoids, a class of natural compounds, are found in various plants, fruits, vegetables, and traditional Chinese medicines. They have anti-inflammatory, antioxidative, and anticarcinogenic properties. Recent studies have shown that some flavonoids strongly inhibit the abnormal contraction of VSM. This review explores the potential of flavonoids as candidate drugs for the treatment and prevention of vasospasm through oxidative stress and the SPC-induced Rhokinase signaling pathway. Nevertheless, more extensive studies are required to fully elucidate the mechanism by which flavonoids exert their anti-vasospastic effects and explore their potential benefits as adjunctive therapy for critical cardiovascular and cerebrovascular diseases.
Keywords: Flavonoids, vasospasm, Oxidative Stress, SPC, ROS
Received: 15 Mar 2025; Accepted: 29 May 2025.
Copyright: © 2025 ZHANG, Maejima, Matsuzaki and Kishi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
YING ZHANG, Faculty of Medicine, Shimane University, Izumo, 693-8501, Shimane, Japan
Hiroko Kishi, Faculty of Medicine, Shimane University, Izumo, 693-8501, Shimane, Japan
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