ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1595177
Stearyl amine-modified elastic cerosomes for boosting the anti-cancer activity of Albendazole
Provisionally accepted
Rofida Albash1*
Hassan Azzazy2
Shaimaa Mosallam3Mohammed I A Hamed4
Khaled Mohamed Darwish5
Maha Mohammed6Lama A Alshabani7
Einas Yousef8
Heba Selim9Ghadeer El-Fadaly1
Asmaa Saleh10Diana E Aziz11- 1Misr University for Science and Technology, 6th of October City, Egypt
- 2American University in Cairo, Cairo, Cairo, Egypt
- 3Faculty of Pharmacy, October 6 University, Giza, Beni Suef, Egypt
- 4Faculty of Pharmacy, Fayoum University, Fayoum, Egypt
- 5Suez Canal University, Ismaïlia, Ismailia, Egypt
- 6beni suef university, beni suef, Egypt
- 7College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
- 8College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- 9University of Almaarefa, Riyadh, Saudi Arabia
- 10Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
- 11Cairo University, Giza, Giza, Egypt
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Background: Albendazole (ALB) is an anthelmintic drug that was repurposed as a chemotherapeutic drug. In this study, ALB was formulated into stearyl amine (SA)-elastic cerosomes (EC) to enhance its anti-cancer efficacy.Methods: Stearyl amine elastic cerosomes loaded Albendazole (SA-EC-ALB) were prepared by thin film hydration. By utilizing D-optimal design using Design-Expert ® software version 7 (Stat-Ease, Inc., Minneapolis, Minnesota, USA). Based on the employed design, 19 formulation were fabricated. The independent variables were SAA amount (X1), sonication time (X2), ceramide type (X3) and SAA type (X4). Entrapment efficiency percent (EE%; Y1), particle size (PS; Y2) and polydispersity index (PDI; Y3) were set as dependent variables.Results: Optimal SA-EC-ALB were prepared using ceramide III and Pluronic L121 with sonication and showed entrapment efficiency percent (EE%) and particle size (PS) of 92.03±3.53% and 312.05±9.32 nm, respectively. The in-silico study showed good interaction between ALB and vesicular components in water. Furthermore, in-vivo anti-tumor assessment of SA-EC-ALB was conducted using solid Ehrlich tumor model in adult Swiss albino male mice and showed significant decrease in tumor volume compared to the control group.Loading ALB in SA-EC has the potential of boosting ALB anti-cancer activity.
Keywords: Albendazole, Repurposing, elastic cerosomes, Stearyl amine, solid Ehrlich
Received: 17 Mar 2025; Accepted: 01 Aug 2025.
Copyright: © 2025 Albash, Azzazy, Mosallam, Hamed, Darwish, Mohammed, Alshabani, Yousef, Selim, El-Fadaly, Saleh and Aziz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rofida Albash, Misr University for Science and Technology, 6th of October City, Egypt
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