REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1595845
Research progress on endoplasmic reticulum homeostasis in acute kidney injury
Provisionally accepted
Huike Chen*
Liling Hu- Zhuzhou Second Hospital, Zhuzhou, China
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The endoplasmic reticulum (ER) is the most metabolically active organelle in cells, and recent research has shown that abnormal ER function is involved in the occurrence and development of acute kidney injury (AKI), but the underlying molecular mechanism needs to be further elucidated. Here, we review the biological functions of the ER in cellular metabolism, explore the current research progress on the role of the ER in different triggers of AKI, and summarize the ER stress inhibitors discovered thus far.Finally, we explore the possibility of targeting ER homeostasis as a therapeutic target for AKI.
Keywords: Endoplasmic reticulum (ER), er stress, Kidney, AKI, upr
Received: 18 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Chen and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huike Chen, Zhuzhou Second Hospital, Zhuzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.