REVIEW article
Front. Pharmacol.
Sec. Drug Metabolism and Transport
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1607210
This article is part of the Research TopicNew Drugs and Future Challenges in Drug Metabolism and TransportView all 22 articles
Advances in Clinical Applications of Microneedle
Provisionally accepted
- 1Nanjing Medical University, Nanjing, China
- 2Southeast University, Nanjing, Jiangsu Province, China
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Microneedle (MN) technology, characterized by its micron-scale structure, can effectively break through the skin barrier, enhance the efficiency of transdermal drug delivery and achieve precise biosignal detection. Research indicates that MNs demonstrate superior safety and efficacy in clinical applications, significantly improving drug delivery efficiency, enhancing patient compliance and reducing side effects. In the field of biosensing, the combination of MN arrays and biosensors enables highly sensitive real-time monitoring of biomarkers. In cancer treatment, MNs exhibit potential for targeted drug delivery, gene therapy, and immunostimulation. Moreover, MNs present broad prospects in wound healing, scar repair, anti-aging and skin disease treatment. This review aims to systematically summarize recent advances in MNs applications across transdermal drug delivery, biosensing, cancer therapy, and skin disease repair through recent high-quality studies, and to explore future development prospects.
Keywords: microneedles, Transdermal drug delivery, Biosignal detection, cancer treatment, personalized medicine
Received: 07 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Chen, Sun, Liu, LI and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dianhuai Meng, Nanjing Medical University, Nanjing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.