New Drugs and Future Challenges in Drug Metabolism and Transport

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ORIGINAL RESEARCH

Accepted on 16 Jun 2025

Influence of Probiotics and Deoxycholate on Azathioprine Transport in the PAMPA Model: Insights into Pharmacomicrobiomics and Interindividual Variability in Drug Response

Maja Ðanic
Nebojsa Pavlovic
Natalija Dedić
Dragana Zaklan
Slavica Lazarević
Bojan Stanimirov
Momir Mikov

doi 10.3389/fphar.2025.1608110

155 views

REVIEW

Accepted on 13 Jun 2025

Advances in Clinical Applications of Microneedle

Kequan Chen
Xinyu Sun
Yangkaiyuan Liu
Shiyu LI
Dianhuai Meng

doi 10.3389/fphar.2025.1607210

208 views

ORIGINAL RESEARCH

Published on 12 Jun 2025

Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice

Linxi Wang
Zhouyangyang Zhang
Menghua Lin
Liqin Qi
Libin Liu
Zhuo Chen
Shuzhi Tang
Lijing Wang

doi 10.3389/fphar.2025.1596655

315 views

ORIGINAL RESEARCH

Accepted on 09 Jun 2025

Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate

Yu Panpan
Jin Xiong
Wu Keheng
Sihui Long
Cheng Shishi
Zhang Mengjun
Fu Long
Xu Xiao
Liu Jie
3 more
Xu Jian

doi 10.3389/fphar.2025.1507828

104 views

ORIGINAL RESEARCH

Published on 28 Apr 2025

Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging

Marco Iannone
Marcelo Kravicz
Paolo Rainone
Antonia I. Antoniou
Stefano Stucchi
Silvia Valtorta
Arianna Amenta
Elia Anna Turolla
Sara Pellegrino
5 more
Rosa Maria Moresco

doi 10.3389/fphar.2025.1566257

1,074 views

ORIGINAL RESEARCH

Published on 09 Apr 2025

Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats

Yang Bai
Rui Wang
Can Jin
Lili Wang
Yun Tang
Han Wang
Kan Ding
Shanjun Cai

doi 10.3389/fphar.2025.1499420

730 views

REVIEW

Published on 18 Mar 2025

Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy

Yutao Zou
Jiayi Chen
Yijie Qu
Xuanxuan Luo
Weiqi Wang
Xiaohua Zheng

doi 10.3389/fphar.2025.1533040

748 views
1 citation

ORIGINAL RESEARCH

Published on 19 Feb 2025

Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study

Junli Lu
Yuyan Lei
Yuanyuan Mo
Xiangping Wang
Wanying Liu
Yu Yan
Hongying Yang
Canxia Li
Lifeng Huang
4 more
Xiaohui Li

doi 10.3389/fphar.2025.1494902

690 views

ORIGINAL RESEARCH

Published on 12 Feb 2025

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

Sadegh Faramarzi
Arianna Bassan
Kevin P. Cross
Xinning Yang
Glenn J. Myatt
Donna A. Volpe
Lidiya Stavitskaya

doi 10.3389/fphar.2024.1451164

1,157 views

ORIGINAL RESEARCH

Published on 08 Jan 2025

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

Weifeng Shan
Shuying Gao
Mengting Ai
Haiyan Lan
Gongchen Duan
Xiaoli Dong
Qiaomin Xu
Yini Wu
Jimin Wu

doi 10.3389/fphar.2024.1427755

1,467 views

ORIGINAL RESEARCH

Published on 08 Jan 2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
4 more
Cheng Yang

doi 10.3389/fphar.2024.1510903

781 views

ORIGINAL RESEARCH

Published on 04 Dec 2024

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

Dongxin Chen
Jie Chen
Hailun Xia
Xiaohai Chen
Jinyu Hu
Guangliang Wu
Xuegu Xu

doi 10.3389/fphar.2024.1498339

655 views
1 citation

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Drug Metabolism and Transport
Experimental Pharmacology and Drug Discovery

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Articles

Influence of Probiotics and Deoxycholate on Azathioprine Transport in the PAMPA Model: Insights into Pharmacomicrobiomics and Interindividual Variability in Drug Response

Advances in Clinical Applications of Microneedle

Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice

Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate

Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging

Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats

Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy

Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

Frontiers in Pharmacology

Drug Metabolism and Transport

Experimental Pharmacology and Drug Discovery