REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1610623
Research progress on peptides that inhibit melanin synthesis
Provisionally accepted
- 1Xinjiang Medical University, Ürümqi, China
- 2Lancaster University, Lancaster, England, United Kingdom
- 3Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong Province, China
- 4Sichuan University of Science and Engineering, Zigong, Sichuan, China
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Melanin produced by melanocytes, primarily determines human skin color and protects against ultraviolet radiation. However, excessive melanin deposition can lead to skin conditions such as freckles, age spots, and moles, potentially causing aesthetic concerns and psychological distress. Consequently, there is significant research interest in developing safe and effective whitening products that inhibit melanin synthesis.Bioactive peptides represent a promising compound category that effectively reduces melanin synthesis with minimal side effects.This review explores melanin pigmentation, identifies sources of peptides that inhibit melanin synthesis, and elucidates the mechanisms by which these peptides operate, aiming to contribute to developing novel whitening products.
Keywords: ：Melanin, excessive deposition, inhibition, tyrosinase, Whitening, Bioactive peptides
Received: 12 Apr 2025; Accepted: 26 May 2025.
Copyright: © 2025 Yu, Wang, Cai, Yan, Sun, Wang, Li and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Lan, Xinjiang Medical University, Ürümqi, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.