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REVIEW article

Front. Pharmacol.

Sec. Neuropharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1620679

This article is part of the Research TopicAdvancing Prevention and Treatment Strategies for Drug-Induced Hearing LossView all articles

Advancing Prevention and Treatment Strategies for Drug-Induced Hearing Loss

Provisionally accepted
  • 1Samford University, Homewood, United States
  • 2University of Alabama at Birmingham, Birmingham, United States
  • 3University of Miami, Coral Gables, Florida, United States

The final, formatted version of the article will be published soon.

Scientific research has significantly propelled advancements in healthcare. One notable application is precision medicine, which seeks to analyze and comprehend disease pathology to offer personalized medical treatments to patients. Targeted oncology, a branch of precision medicine, focuses on identifying and targeting specific molecules that regulate cancer cells, thereby minimizing harm to healthy cells. Different types of targeted therapy against cancer include monoclonal antibodies and small molecules. This manuscript intends to provide an overview of the influence of these targeted oncology and non-oncology therapies on hearing. Furthermore, side effects including immune-related adverse events will be reviewed as potential causes of hearing deterioration in this patient population. This manuscript reviews targeted oncology therapies as a subset of precision medicine, focusing on the existing evidence of ototoxicity and vestibulotoxicity in mAb and small molecule therapies.

Keywords: ototoxicity, targeted therapies, monoclonal antibodies, Hearing Loss, small molecules

Received: 30 Apr 2025; Accepted: 29 Jul 2025.

Copyright: © 2025 Bonilla, DiFatta, Bas Infante and Goncalves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Stefania Goncalves, University of Alabama at Birmingham, Birmingham, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.